Example sentences for: tolerability

How can you use “tolerability” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Nonetheless, there has been a large body of literature dedicated to the positive effects of peripheral alpha-1 antagonists on surrogate endpoints such as cholesterol levels and tolerability.

  • Even though most statins share similar tolerability, some evidence shows that atorvastatin has greater dose-specific potency for lowering LDL-C and total cholesterol [22].

  • Safety and tolerability trials with terazosin have shown similar results (Table 1).

  • Saltissi, et al [ 11 ] recently reported the tolerability and effectiveness of simvastatin in doses of 5-20 mg in lowering LDL and non-HDL cholesterol in dialysis patients.

  • To reduce APV pill burden and possibly improve tolerability of APV treatment, pharmacokinetic research efforts have been directed at combining APV with the PI ritonavir (RTV), which inhibits CYP3A4-mediated hepatic metabolism of APV, thereby enhancing plasma APV exposure [ 13 14 15 ] . The administration of RTV at the clinically sub-therapeutic dosage of 100 mg BID was found to boost APV plasma exposure to such a degree as to permit halving the APV daily pill burden from 16 to 8 capsules/day, in addition to maintaining the minimum plasma APV concentration (C min ) over 24 hours well above the 50% inhibitory concentrations (IC 50 ) of patient-derived HIV-1 isolates [ 15 ] . A pharmacokinetic study in 20 HIV-infected patients, PROF1004, showed that APV at the lower dosage of 600 mg BID combined with RTV 100 mg BID (APV600/RTV) resulted in a geometric mean steady-state APV C min (1.


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