Words similar to tnrc
Example sentences for: tnrc
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Long polyglutamine repeats have been found in a number of transcription factors [ 39 ] . Notably, the C-terminus of murine HMG-box protein SRY contains a large polyglutamine repeat region that is responsible for the sex-determining function of this protein [ 40 ] . However, a number of neurodegenerative disorders, such as Huntington disease and spinobulbar muscular atrophy, are also strongly associated with proteins containing a polyglutamine stretch [ 41 ] . Conformational change and protein misfolding in the expanded polyglutamine region is believed to be the molecular basis of the pathogenesis [ 42 ] . Whether the presence of polyglutamine repeats in the C-terminus of human TNRC9 is important for function or alternatively hinders its ability to form a functional protein remains to be determined.
The C-terminal domain of TNRC9 contains an expansion of trinucleotide repeats coding for glutamine.
Based on sequence comparison with human TNRC9, we believe that this represents an error generated by automated computational analysis.
Human sequences : KIAA0808 mRNA (AB018351), KIAA0808 protein (BAA34528); KIAA0737 (C14ORF92) mRNA (NM_014828), KIAA0737 predicted protein (NP_055643); C20ORF100 mRNA (NM_032883), C20ORF100 predicted protein (NP_116272); TNRC9 mRNA (XM_049037), TNRC9 predicted protein (XP_049037), SEX determining region Y protein (SRY) (XP_010468).
The C-terminal domains of TOX/ KIAA0808 and LOC244579/ TNRC9 are mildly to strongly basic respectively, while those of LCP1 and KIAA0737 are acidic.
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