Example sentences for: tightly

How can you use “tightly” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • At low moi, the bacilli were tightly clustered into a single vacuole throughout the observed time period.

  • To test if COP1 is tightly bound to the NE, we extracted cells with 1% Triton X-100 before fixation.

  • Furthermore, nuclear labeling and DNA synthesis appeared tightly associated in SH-SY5Y cultures, consistent with the suspected role of lamins in DNA replication [ 8 ] . Others have reported SMI-31 labeling in glial as well as neuronal nuclei.

  • Normal wound healing requires fibroblast proliferation and migration into the wound bed followed by tightly regulated matrix deposition and contraction.

  • The ability of a MIDAS protein to bind its protein ligand is tightly linked with the presence of intact MIDAS motifs: mutations to the metal-coordinating residues in these motifs, weaken or eliminate ligand binding [ 35 36 ] . An additional set of MIDAS-like proteins, that includes the integrin β-chain [ 37 38 ] and the von Willebrand Factor A domain [ 27 ] , lacks one of the three motifs and appears to bind ligands in a somewhat different manner [ 27 39 40 ] . In midasin, the presence of all three MIDAS motifs in the M-domain, with the putative metal ion-binding residues in the motifs invariant in the available organisms, indicates that midasin belongs to the family of MIDAS-containing proteins.


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