Example sentences for: tightly

How can you use “tightly” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The potential role of CSN as an organizing center for certain enzymatic activities may not be restricted to the control of cullin neddylation, as CSN was also shown to mediate phosphorylation of c-JUN, IkBa, and p53 by a tightly associated kinase(s) [ 12, 19].

  • i for analog 2 suggests that analog 2 binds weakly to Y152 while lerisetron and analog 1 bind more tightly.

  • In Modern English (1873), he harassed other self-proclaimed authorities, and, in both books, three or four lines of text float above a dense mass of footnotes in tightly set six-point type.

  • By day you’ll have to pick your way across the beach through a sea of tightly packed bodies — despite the inconveniences, Platja de Palma is an outstanding long (4.

  • Mediators known to activate ECs include inflammatory cytokines, growth factors such as VEGF/VPF and basic fibroblast growth factor (bFGF), extracellular matrix (ECM) proteins such as collagen and fibronectin, and proteases such as MMPs [ 1 2 ] . In vitro and in vivo assays indicate that VEGF signaling promotes increased permeability, cell migration, proliferation, and differentiation, functioning through two EC-specific tyrosine kinase receptor such as Kinase domain receptor (KDR) [ 1 2 3 ] . In the majority of solid tumors, VEGF is upregulated in response to hypoxia, inducing the expression of pro-angiogenic genes that promote tumor angiogenesis, growth and eventual metastasis [ 3 4 5 ] . The expression of both positive and negative factors must be tightly and specifically regulated in a coordinated manner.


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