Example sentences for: tightly

How can you use “tightly” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Consistent with this observation, studies of detergent-induced dissociation of LHCs suggested that Chl b is held by the proteins approximately two-times more tightly than Chl a [ 24 ] . Tighter binding of Chl b is apparently responsible for the well-known stability of light-harvesting complexes during mildly denaturing gel electrophoresis.

  • The T m of the 5' OCP arm is greater than the reaction temperature and so the OCP tightly anneals to the target.

  • Mediators known to activate ECs include inflammatory cytokines, growth factors such as VEGF/VPF and basic fibroblast growth factor (bFGF), extracellular matrix (ECM) proteins such as collagen and fibronectin, and proteases such as MMPs [ 1 2 ] . In vitro and in vivo assays indicate that VEGF signaling promotes increased permeability, cell migration, proliferation, and differentiation, functioning through two EC-specific tyrosine kinase receptor such as Kinase domain receptor (KDR) [ 1 2 3 ] . In the majority of solid tumors, VEGF is upregulated in response to hypoxia, inducing the expression of pro-angiogenic genes that promote tumor angiogenesis, growth and eventual metastasis [ 3 4 5 ] . The expression of both positive and negative factors must be tightly and specifically regulated in a coordinated manner.

  • Most importantly, a large region flanking the KO gene remains of 129 origin, unless extreme measures are taken to select for recombination between tightly linked markers.

  • Discussions of transcriptional regulation often emphasize the belief that the process is tightly controlled and essentially error-free.


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