Words similar to thioureylenes

Example sentences for: thioureylenes

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The efficacy of antithyroid thioureylenes as agents in the treatment of plaque psoriasis is well established [ 4 5 7 8 ] The mechanism of action of these agents in psoriasis remains unclear.
[ 1 2 ] Treatment of the disease results in costs that range between 0.7 to more than 4 billion dollars annually in the US alone [ 3 ] . One of the most cost-effective forms of potential treatment for the disease is the use of antithyroid thioureylenes such a propylthiouracil.
We previously reported the effectiveness of thioureylene treatment in patients with plaque psoriasis [ 4 5 6 7 ] , a finding since confirmed by others [ 8 ] . The mechanism of action of antithyroid thioureylenes in psoriasis remains unclear.
The drugs have been studied with relation to their effect in Graves' hyperthyroidism which, like psoriasis, is an autoimmune disorder [ 9 10 11 12 ] Antithyroid thioureylenes, of which propylthiouracil, methimazole and carbimazole are used in clinical practice, have known immunomodulatory properties [ 13 14 ] and, in the case of psoriasis, also have antiproliferative effects as demonstrated by their ability to produce a decline in markers of cellular proliferation such as proliferative cell nuclear antigen (PCNA) [ 15 ] .