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Together, these data suggest that myelin-associated neurite-growth inhibitory activity may contribute to the parallel constraint on growth in white matter but do not necessarily implicate specific inhibitors since priming with neurotrophins and treatment with cAMP analogs inactivate the inhibitory activity of myelin as a whole [ 35, 36].
These objects can now be analyzed to characterize the sequences for quantities such as similarity between segments or entropy [ 18 19 ] within the sequence.
Finally, it should be emphasized that these cautionary notes on application of computational methods in protein function prediction in no way suggest that new computational approaches that depart sharply from more established ones are doomed to failure.
And while Dunlap seems to harbor no trace of self-doubt, the impulse to quiet these critics must have been fairly strong.
How long I've waited to write these words.