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Fourth, we should seek further external validation of these results, along the lines of the vital registration-based analysis conducted for Mexico and Brazil.
Based on these findings, trials to address obesity in older women could be efficient if YHL (but not YOL) was the outcome measure.
For example, the known targets of the oxidative stress-responsive transcription factor Yap1p are coordinately induced in response to conditions that inflict oxidative damage, but these genes are divergently expressed in response to other environmental changes (Figure 1c) [ 2].
Taken together, these studies suggest a complex network of positive and negative regulatory pathways controlling key virulence genes in S. pyogenes that can be activated or inactivated in response to certain biological pressures in the infected host.
'Matched isologs' are sequences that have a high degree of similarity (score of over 100 at the protein level) to a gene found in another organism, but a functional homology between these genes has not been determined.