Words similar to theca
Example sentences for: theca
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The bone morphogenetic protein (BMP) family including ligands, receptors, and binding proteins, has emerged as a central player in ovary physiology and female fertility [ 1 ] . The BMPs represent a large subclass of the transforming growth factor-β (TGF-β) surperfamily of ligands whose biological responses are mediated by Ser/Thr kinase receptors via the Smad-signaling molecules [ 2 ] . The mRNAs encoding several BMP family members have been identified in the murine ovary, including the ligands, BMP-2 [ 3 ] , BMP-3 [ 3 ] , BMP-3b [ 3 ] , BMP-4 [ 4 ] , BMP-6 [ 5 ] , BMP-7 [ 4 ] , BMP-15 [ 6 7 8 ] , the BMP receptors, BMPR-IA, BMPR-IB and BMPR-II [ 4 ] and the BMP binding protein, follistatin (FS) [ 9 ] . In the murine, BMP-4 and -7 mRNA have been identified in the theca interstitial cells [ 4 ] , BMP-6 and -15 in oocytes [ 5 6 7 8 ] , BMPR-IA, BMPR-IB and BMPR-II in oocytes and granulosa cells (GCs) [ 4 ] , and FS in granulosa and lutein cells [ 9 10 ] .
This, together with the failure to detect BMP-4 and 7 in the theca of atretic follicles, supports the idea that the cellular sites and coordinate expression of these BMP genes may have important regulatory roles in maintaining folliculogenesis.
In the theca, some TIC and TE cells showed BMPR-IB expression with the highest levels appearing in dominant follicles at proestrus (Table 1, Fig.
BMP-4 mRNA was expressed at high levels in the theca of developing dominant follicles, again being localized to the TE and adjacent TIC (Fig.
First, a striking feature of atresia in the rat ovary is the cessation of BMP expression (BMP-3b, -4, and -7) within the theca compartment.
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