Words similar to theca
Example sentences for: theca
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The theca of developing follicles first exhibited BMP-7 mRNA when the second layer of GC appeared, i.e. at the primary/secondary follicle transition (Table 1).
The bone morphogenetic protein (BMP) family including ligands, receptors, and binding proteins, has emerged as a central player in ovary physiology and female fertility [ 1 ] . The BMPs represent a large subclass of the transforming growth factor-β (TGF-β) surperfamily of ligands whose biological responses are mediated by Ser/Thr kinase receptors via the Smad-signaling molecules [ 2 ] . The mRNAs encoding several BMP family members have been identified in the murine ovary, including the ligands, BMP-2 [ 3 ] , BMP-3 [ 3 ] , BMP-3b [ 3 ] , BMP-4 [ 4 ] , BMP-6 [ 5 ] , BMP-7 [ 4 ] , BMP-15 [ 6 7 8 ] , the BMP receptors, BMPR-IA, BMPR-IB and BMPR-II [ 4 ] and the BMP binding protein, follistatin (FS) [ 9 ] . In the murine, BMP-4 and -7 mRNA have been identified in the theca interstitial cells [ 4 ] , BMP-6 and -15 in oocytes [ 5 6 7 8 ] , BMPR-IA, BMPR-IB and BMPR-II in oocytes and granulosa cells (GCs) [ 4 ] , and FS in granulosa and lutein cells [ 9 10 ] .
An intriguing feature of theca BMP-7 mRNA expression is that it restricted to the inner most layer, being present in a subset of fibroblast-like cells juxtaposed to the basal lamina and a sub-population of adjacent TIC (Fig.
In the theca, BMPR-IA mRNA expression was not notable, except for a stage-specific increase among the early tertiary follicles at P 1000 h (Fig.
Very little is known about the role of the TE in folliculogenesis: however this new finding raises the possibility that BMP-3b and -4 could have autocrine actions on TE histogenesis and/or paracrine actions on theca/follicle morphogenesis.
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