Words similar to theca
Example sentences for: theca
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In this regard, a recent study has demonstrated the ability of BMP-4 to inhibit cyclic AMP-stimulated androgen production by the cultured human theca cell line, presumably by activating BMP receptors (BMPR-IA, -IB, and -II) which are expressed in these cells [ 34 ] . Because theca derived androgen is required for follicle estrogen biosynthesis and has been implicated in ovary pathology [ 35 ] , it will be interesting to determine how the expression and functions of these TIC-specific BMPs are integrated into the overall processes of physiology and pathophysiology.
1A) and ovarian interstitial cells (i), follicular theca interna (t, Fig.
BMP-4 mRNA was expressed in a variety of ovary cell types with the highest levels appearing in the theca, CL, OSE, SC and endothelium of some blood vessels (Table 1, Fig.
The bone morphogenetic protein (BMP) family including ligands, receptors, and binding proteins, has emerged as a central player in ovary physiology and female fertility [ 1 ] . The BMPs represent a large subclass of the transforming growth factor-β (TGF-β) surperfamily of ligands whose biological responses are mediated by Ser/Thr kinase receptors via the Smad-signaling molecules [ 2 ] . The mRNAs encoding several BMP family members have been identified in the murine ovary, including the ligands, BMP-2 [ 3 ] , BMP-3 [ 3 ] , BMP-3b [ 3 ] , BMP-4 [ 4 ] , BMP-6 [ 5 ] , BMP-7 [ 4 ] , BMP-15 [ 6 7 8 ] , the BMP receptors, BMPR-IA, BMPR-IB and BMPR-II [ 4 ] and the BMP binding protein, follistatin (FS) [ 9 ] . In the murine, BMP-4 and -7 mRNA have been identified in the theca interstitial cells [ 4 ] , BMP-6 and -15 in oocytes [ 5 6 7 8 ] , BMPR-IA, BMPR-IB and BMPR-II in oocytes and granulosa cells (GCs) [ 4 ] , and FS in granulosa and lutein cells [ 9 10 ] .
The highest expression was in the oocytes, GC, theca, and CL, with the greatest concentrations appearing in developing oocytes (Table 1).
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