Example sentences for: thapsigargin

How can you use “thapsigargin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The effects of mefloquine on ER calcium homeostasis have been examined previously [ 5 6 ] . In experiments with isolated rabbit skeletal muscle microsomes, mefloquine was found to inhibit the uptake of calcium, with an IC 50 of approximately 43 μM [ 6 ] . This effect was exacerbated by treatment with thapsigargin, a specific inhibitor of the ER calcium pump [ 6 ] . Further, the rate of ATP hydrolysis by the ER Ca 2+-ATPase was reduced in the presence of mefloquine (Ki of = 53 μM).

  • Rat neurons were pretreated with either thapsigargin (4 μM) or DMSO (0.

  • Mefloquine (80 μM), thapsigargin (4 μM) or DMSO (0.

  • thapsigargin) on the ER Ca 2+-ATPase results in a decrease in the rate of calcium influx across the ER membrane.

  • Thapsigargin blocked both the initial and secondary rises in cytoplasmic calcium induced by mefloquine and partially reversed the neurotoxicity of the drug.


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