Words similar to thapsigargin

Example sentences for: thapsigargin

How can you use “thapsigargin” in a sentence? Here are some example sentences to help you improve your vocabulary:

We next investigated the possibility that thapsigargin pretreatment might have a protective effect on neurons exposed to mefloquine.
The effects of mefloquine on ER calcium homeostasis have been examined previously [ 5 6 ] . In experiments with isolated rabbit skeletal muscle microsomes, mefloquine was found to inhibit the uptake of calcium, with an IC 50 of approximately 43 μM [ 6 ] . This effect was exacerbated by treatment with thapsigargin, a specific inhibitor of the ER calcium pump [ 6 ] . Further, the rate of ATP hydrolysis by the ER Ca 2+-ATPase was reduced in the presence of mefloquine (Ki of = 53 μM).
The most reasonable interpretation of these data is that mefloquine mobilizes a thapsigargin-sensitive calcium pool, and, since thapsigargin is known to mobilize the ER calcium pool, that this is also the case for mefloquine.
The antagonisation by mefloquine of the ER calcium release induced by thapsigargin, a specific inhibitor of the ER calcium pump, suggests that mefloquine mobilizes ER calcium stores.
[ 6 ] , that the effects of mefloquine and thapsigargin on microsomal calcium uptake are synergistic, might seem at first to contradict ours.