Words similar to thapsigargin

Example sentences for: thapsigargin

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Neuroprotective effect of thapsigargin
The effects of mefloquine on ER calcium homeostasis have been examined previously [ 5 6 ] . In experiments with isolated rabbit skeletal muscle microsomes, mefloquine was found to inhibit the uptake of calcium, with an IC 50 of approximately 43 μM [ 6 ] . This effect was exacerbated by treatment with thapsigargin, a specific inhibitor of the ER calcium pump [ 6 ] . Further, the rate of ATP hydrolysis by the ER Ca 2+-ATPase was reduced in the presence of mefloquine (Ki of = 53 μM).
Under the conditions employed in our study, it is not surprising that mefloquine antagonized the effect of thapsigargin.
Mefloquine (2, 10, 30, 60, 80 or 200 μM), thapsigargin (1 μM), glutamate (1 μM) and CaCl 2 (1.
Thapsigargin antagonizes the disruptive effect of mefloquine on calcium homeostasis and protects neurons from cellular injury