Words similar to thapsigargin
Example sentences for: thapsigargin
How can you use “thapsigargin” in a sentence? Here are some example sentences to help you improve your vocabulary:
The effects of mefloquine on ER calcium homeostasis have been examined previously [ 5 6 ] . In experiments with isolated rabbit skeletal muscle microsomes, mefloquine was found to inhibit the uptake of calcium, with an IC 50 of approximately 43 μM [ 6 ] . This effect was exacerbated by treatment with thapsigargin, a specific inhibitor of the ER calcium pump [ 6 ] . Further, the rate of ATP hydrolysis by the ER Ca 2+-ATPase was reduced in the presence of mefloquine (Ki of = 53 μM).
Rat neurons were pretreated with either thapsigargin (4 μM) or DMSO (0.
Mefloquine (80 μM), thapsigargin (4 μM) or DMSO (0.
thapsigargin) on the ER Ca 2+-ATPase results in a decrease in the rate of calcium influx across the ER membrane.
Thapsigargin blocked both the initial and secondary rises in cytoplasmic calcium induced by mefloquine and partially reversed the neurotoxicity of the drug.