Words similar to thapsigargin

Example sentences for: thapsigargin

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The degree of neuroprotection afforded by thapsigargin was basically the extent to which the drug reversed the decline in absorbance (viability) induced by mefloquine and was calculated as previously described [ 14 ] .
The effects of mefloquine on ER calcium homeostasis have been examined previously [ 5 6 ] . In experiments with isolated rabbit skeletal muscle microsomes, mefloquine was found to inhibit the uptake of calcium, with an IC 50 of approximately 43 μM [ 6 ] . This effect was exacerbated by treatment with thapsigargin, a specific inhibitor of the ER calcium pump [ 6 ] . Further, the rate of ATP hydrolysis by the ER Ca 2+-ATPase was reduced in the presence of mefloquine (Ki of = 53 μM).
We next investigated the possibility that thapsigargin pretreatment might have a protective effect on neurons exposed to mefloquine.
Neuroprotective effect of thapsigargin
thapsigargin) on the ER Ca 2+-ATPase results in a decrease in the rate of calcium influx across the ER membrane.