Words similar to thalassemia
Example sentences for: thalassemia
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The thalassemias are a group of inherited disorders of hemoglobin [ 1 ] , the most severe form of which is beta thalassemia major.
Based on analyses of individual patient data from eight studies reporting on changes in HIC over time, desferrioxamine seems to be more effective than deferiprone in lowering hepatic iron in patients with thalassemia major.
The National Library of Medicine's computerized bibliographic database (Medline 1966 to December 1999) was searched using a combination of the following keywords: thalassemia, serum ferritin, urinary iron excretion, hepatic iron, liver, chelation therapy, iron chelation, iron chelating agents, desferal, desferrioxamine, deferoxamine, L1 oral chelate, deferiprone and 1,2-dimethyl-3-hydroxypyrid-4-one.
It has been said that a meta-analysis is only useful until the next good trial comes along [ 29 ] . In the case of iron chelation therapy for patients with thalassemia major, the addition of any good prospective randomized control trial documenting the impact of treatment on body iron (hepatic and/or myocardial) would contribute measurably to the evaluation of the long-term implications of treatment with deferiprone, compared to desferrioxamine.
Improvements in the management of patients with thalassemia major in the past four decades have resulted in "one of the most dramatic alterations in morbidity and mortality associated with a genetic disease" [ 2 ] . Regular red blood cell transfusions extend survival, eliminate complications of anemia, inhibit bone marrow hyperactivity, and support normal growth and development in patients with thalassemia major [ 3 ] . Unfortunately, regular transfusions also lead to the accumulation of tissue iron, loading the body's organs to the point of dysfunction and finally death in the second or third decade of life if left untreated [ 4 ] .
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