Words similar to thalassemia
Example sentences for: thalassemia
How can you use “thalassemia” in a sentence? Here are some example sentences to help you improve your vocabulary:
While no one method is superior for all clinical scenarios, until recently measurement of hepatic iron stores - through liver biopsy or magnetic susceptometry - has provided the most quantitative, specific and sensitive method for determining the body iron burden in patients with thalassemia major and was considered the reference method for comparison with other techniques [ 2 4 ] . In the future, the newer advanced magnetic-resonance techniques, which allow for the assessment of both liver and cardiac iron, might provide an even more accurate assessment of total body iron [ 5 ] . Measurement of the magnitude of iron loading is useful in evaluating the effectiveness of the chelating agent, calibrating patient-specific treatment, and, in clinical research, as a determinant of clinical outcome.
Measurement of HIC has been established in the field as the reference method for assessing total body iron burden in thalassemia major, and therefore preferred for research purposes.
Improvements in the management of patients with thalassemia major in the past four decades have resulted in "one of the most dramatic alterations in morbidity and mortality associated with a genetic disease" [ 2 ] . Regular red blood cell transfusions extend survival, eliminate complications of anemia, inhibit bone marrow hyperactivity, and support normal growth and development in patients with thalassemia major [ 3 ] . Unfortunately, regular transfusions also lead to the accumulation of tissue iron, loading the body's organs to the point of dysfunction and finally death in the second or third decade of life if left untreated [ 4 ] .
All studies of desferrioxamine and deferiprone usage in thalassemia major patients - whether randomized, blinded, comparative, case series, or cross-over - irrespective of language were considered eligible for inclusion in the analysis.
The National Library of Medicine's computerized bibliographic database (Medline 1966 to December 1999) was searched using a combination of the following keywords: thalassemia, serum ferritin, urinary iron excretion, hepatic iron, liver, chelation therapy, iron chelation, iron chelating agents, desferal, desferrioxamine, deferoxamine, L1 oral chelate, deferiprone and 1,2-dimethyl-3-hydroxypyrid-4-one.
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