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Example sentences for: tenascin
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The presence of TGF-β increases the expression of such extracellular matrix proteins as fibronectin, the fibronectin receptor, vitronectin, tenascin, elastin, thrombospondin, collagen, and biglycan [ 25 26 27 28 29 30 31 32 ] and also inhibits expression of proteases that degrade the extracellular matrix while stimulating the expression of protease inhibitors [ 33 34 35 36 ] .
For example, cadherin 13 ( CDH13 ), versican ( CSPG2 ), collagen 8A1 ( COL8A1 ), collagen 12A1 ( COL12A1 ), P4HA2 (encoding a procollagen-modifying enzyme) all showed relatively low expression in the genital skin fibroblasts of normal males, whereas tenascin XB ( TNXB ), nidogen 2 ( NID2 ), laminins ( LAMA3 , LAMA4 ) and tissue inhibitor of metalloproteinase 1 ( TIMP1 ) all showed relatively high expression levels compared to AIS-derived fibroblasts (Figure 2).
A possible physiologic consequence of IL-1β-induced tenascin expression is that it may promote chondrocyte migration towards the sites of lesions in OA [ 47].
Similarly, in birds, a polymorphism at the tenascin locus (which lies a few megabases proximal to Tlr4 in mice) predicts susceptibility to Gram-negative infection [ 30], suggesting that it may lie in linkage disequilibrium with a particular form of the avian Tlr4 gene.
As the clot is digested by plasmin, fibroblasts replace it with cellular FN, tenascin (TN) and Coll III [ 12 13 ] . These extracellular matrix proteins are critical for migration of endothelial cells, keratinocytes and additional fibroblasts into the wound and are important for proper generation of healthy healing tissue.
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