Words similar to temperature-sensitive

Example sentences for: temperature-sensitive

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A temperature-sensitive mutant of the yeast PP1 (Glc7), for example, exhibits a block in the M phase of the cell division cycle, and elevated expression of Sds22 suppresses this defect [ 38 ] . Structure-function analysis of recombinant mammalian PP1 has recently begun to map specific residues involved in interaction with other molecules.
Moreover, the arrest of cdc5-1 , cdc5-2 , cdc5-4 , and cdc5-7 temperature-sensitive mutants in late mitosis was potently suppressed by the TAB6-1 allele (Park et al.
When cells harboring conditional-lethal temperature-sensitive (ts) mutations in any of these proteins are shifted to the restrictive temperature, they uniformly arrest in late anaphase as large-budded cells with segregated chromosomes, fully elongated microtubule spindles, and in all tested cases, elevated Cdc28/Clb2 protein kinase activity (Cdc28 is the major cyclin-dependent kinase Cdk1 and Clb2 the major mitosis-specific cyclin of budding yeast) (reviewed in [ 1 ] , [ 2 ] ).
This prediction was then validated experimentally by showing that MJ1477 had CysRS activity in vitro and that an ortholog of MJ1477 from D. radiodurans, DR0705, complemented a CysRS deficient, temperature-sensitive, lethal E. coli mutant strain [ 18].
The cdc25 +gene encodes a positive mitotic regulator [ 50 ] that is also a target of DNA damage checkpoint signaling [ 51 ] . At the restrictive temperature (37°C), the temperature-sensitive cdc25.