Words similar to tel-sam

Example sentences for: tel-sam

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The wild-type TEL-SAM polymer forms large insoluble aggregates, which precludes structure determination.
We used the Quickchange kit (Stratagene) to generate site directed mutants, V80R and A61D from wild-type TEL-SAM cloned into a modified pET3c vector (Novagen) [ 7 ] . The expressed protein sequence includes an MEKTR leader sequence, followed by residues 38-124 of the TEL protein and then a C-terminal His tag.
We were, however, able to obtain a structure of a mutant TEL-SAM polymer, V80E [ 7 ] . The V80E mutation is in the center of the polymer interface and reduces the affinity of subunit association enough that the protein is relatively soluble above pH 7.0, where the Glu side chain is deprotonated.
The Ph-SAM polymer is quite similar to the TEL-SAM polymer even though the proteins have an unrelated domain structure and show less than 20% sequence identity between the SAM domains.
In this report we have extracted a TEL-SAM dimer from the wild-type polymer and present its crystal structure.