Words similar to tec

Example sentences for: tec

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Some of the earliest changes that occur following BCR engagement are the activation of several non-receptor protein tyrosine kinases (PTKs), including p55 blk (Blk), p59 fyn (Fyn) and p53/56 lyn (Lyn) of the Src family [ 31 ] , Btk of the Itk/Tec family [ 32 33 ] and p72 Syk (Syk) of the Syk/ZAP-70 family [ 34 ] . The importance of Syk in BCR signaling and lymphocyte development has been clearly demonstrated using gene inactivation approaches.
Although our original SH3 domain binding experiments suggested a specific interaction between Tec kinases and the Src kinases Fyn, Lyn and Hck, we have been able to observe both activation by and co-precipitation with other Src family kinases including Lck and Src in 293T cells (data not shown).
It is now clear that the other Tec kinases participate in similar signaling cascades in multiple cell-types.
Tec1p, conspicuously absent in our model, has not been observed to interact with any proteins in high-throughput two-hybrid screens.
Because of the complex interdependence of TEC and thymocyte differentiation, defects in fetal TEC development can be caused either directly by cell-autonomous TEC differentiation defects, or indirectly by defective thymocyte maturation.