Words similar to tcrs
Example sentences for: tcrs
How can you use “tcrs” in a sentence? Here are some example sentences to help you improve your vocabulary:
A plethora of computational methods has been developed to find over-represented sequences in a subset of genes believed to contain a common transcription factor binding site (reviewed in [ 11 ] ). The rapid pace of genome sequencing has enabled a complementary approach - phylogenetic footprinting (reviewed in [ 12 13 ] ) - which recognizes that the conservation of sequences across related organisms often reflects evolutionary selection for their presence in TCRs.
We expect that if a sequence feature represented a transcription factor binding site, genes containing that feature in their TCRs would be induced (or repressed), on average, compared to all the genes in the genome [ 27 ] . By comparing the average expression profile derived from conserved word-pair templates with average expression profiles derived from simpler sequence features, we assessed how much information was obtained by incorporating both the conservation and pairwise combination of sequences.
Conservation was assessed using the genome sequences of Saccharomyces cerevisiae and three closely related Saccharomyces species, which had been sequenced to identify conserved regulatory sequences [ 26 ] . To exploit this comparative genomic data, we have devised a method that systematically tested sequence pairs for joint conservation across genomes and close spacing within individual TCRs.
In addition, many gene subsets that shared an individual word-pair template in their TCRs were highly enriched for gene-expression changes.
are indicator variables for the presence of each conserved word in a TCR, summed over all TCRs.
Loading...