Words similar to taxol

Example sentences for: taxol

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For Taxol, application of commonly applied force fields as well as the semiempirical methods AM1 and PM3 results in an ordering of conformational energies that is method dependent and mostly inconsistent with experimental data.
For example, a cephalosporin-doxorubicin prodrug was 9-fold less toxic than free doxrubicin against tumor cells in vitro, but caused tumor regression when tested in tumor xenograft models [ 40 ] . A cephalosporin-vinca alkaloid prodrug was 5-fold less toxic than the free drug against tumor cells in vitro, but was highly effective in tumor xenograft models in vivo [ 41 ] . When taxol was conjugated to a cephalosporin, the resulting prodrug was approximately 10-fold less toxic than free taxol against tumor cells in vitro [ 36 ] . Thus, prodrug 2 has the potential to be useful in cancer treatment using the ADEPT approach.
The final two Taxol conformers included in our dataset, 6 and 7 , appear together in the unit cell of an X-ray crystal structure determination.
Addition of phalloidin, taxol, or PEG did not make a difference either (data not shown).
Rotamer 4 corresponds to the recently proposed bioactive conformation of Taxol bound to β-tubulin.