Words similar to taxol
Example sentences for: taxol
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Taxol includes ten polar functionalities: five 3-atom units (four esters, one amide) and five 1- or 2-atom units (three OHs, one ether, one C9 carbonyl).
The latter compound differs constitutionally from Taxol in that the C10 acetate becomes an OH and the NHC(=O)Ph benzamido group is replaced by NHC(=O)O- t -Bu.
[ 15 ] The latter is a C13 side chain extended structure, while hydrophobically collapsed 6 is very similar to 5 . Table 1complements Figure 3in providing a selected set of dihedral angles to illustrate explicitly the conformational variation among the seven Taxol torsional isomers.
Rotamer 4 corresponds to the recently proposed bioactive conformation of Taxol bound to β-tubulin.
This conformer was assigned a low population in the multi-conformational analysis of Taxol in chloroform [ 12 ] , used in the fitting of the electron crystallographic density of the β-tubulin/Taxol complex in zinc-stabilized sheets, and ultimately assessed as the binding conformation for Taxol in this structure.