Words similar to taxol
Example sentences for: taxol
How can you use “taxol” in a sentence? Here are some example sentences to help you improve your vocabulary:
To evaluate the energetic performance of various computational schemes, seven Taxol conformations derived from experimental data with differing torsional angles in the C13 fragment were examined.
For example, a cephalosporin-doxorubicin prodrug was 9-fold less toxic than free doxrubicin against tumor cells in vitro, but caused tumor regression when tested in tumor xenograft models [ 40 ] . A cephalosporin-vinca alkaloid prodrug was 5-fold less toxic than the free drug against tumor cells in vitro, but was highly effective in tumor xenograft models in vivo [ 41 ] . When taxol was conjugated to a cephalosporin, the resulting prodrug was approximately 10-fold less toxic than free taxol against tumor cells in vitro [ 36 ] . Thus, prodrug 2 has the potential to be useful in cancer treatment using the ADEPT approach.
The latter compound differs constitutionally from Taxol in that the C10 acetate becomes an OH and the NHC(=O)Ph benzamido group is replaced by NHC(=O)O- t -Bu.
This conformer was assigned a low population in the multi-conformational analysis of Taxol in chloroform [ 12 ] , used in the fitting of the electron crystallographic density of the β-tubulin/Taxol complex in zinc-stabilized sheets, and ultimately assessed as the binding conformation for Taxol in this structure.
For Taxol, application of commonly applied force fields as well as the semiempirical methods AM1 and PM3 results in an ordering of conformational energies that is method dependent and mostly inconsistent with experimental data.
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