Words similar to target-specific
Example sentences for: target-specific
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The 5' target-specific region of the OCP is 20-30 bp in length, while the 3' target-specific region is 12-20 bp [ 12 ] . The Tm of the 5' target specific region is ∼ 5°C above the ligation temperature, while that of the 3' target specific region is ∼ 15°C below the ligation temperature.
They are partly target- and partly backbone-specific, corresponding to the 3' target-specific region of the OCP, and 7-12 nucleotides of the adjacent backbone sequence.
Upon ligation, the DNA circle creates an effective template for an exponential, or hyperbranching, RCA reaction [ 6 11 ] . The region of the OCP between the target-specific ends, which we have designated the OCP backbone, provides a binding site for a complementary primer (P1).
Results are shown in Figure 4and Table 5. Since library construction was based on peptides previously selected for binding and selectivity to specific RNAs, the number of target-specific clones increased dramatically following in vitro maturation.