Words similar to tamoxifen
Example sentences for: tamoxifen
How can you use “tamoxifen” in a sentence? Here are some example sentences to help you improve your vocabulary:
It is possible that tamoxifen is only effective in inducing TGF-β in the context of a tumor, and not in normal or initiated tissue, which was the subject of the present study.
In rats receiving tamoxifen at 10 mg/kg per day intragastrically (equivalent to 600 mg/day for a human) or 1 mg/kg per day (equivalent to 60 mg/day for a human) for either 1 day or 3 weeks, again no consistent changes were seen in TGF-β expression, using either the TGF-β 1 -CC or the TGF-β 2 antibodies (data not shown).
Most of the previous studies on the regulation of TGF-βs by tamoxifen and retinoids [ 12, 13, 14, 17] have been done in tissue culture.
In the present study, we used a carcinogen-induced rat model of mammary carcinogenesis to test whether chemoprevention by tamoxifen and by two different retinoids (4-HPR, also known as fenretinide; and 9-cRA) is associated with local upregulation of TGF-βs in the initiated mammary gland.
In this regard, our demonstration that the expression of TGF-βs in the preclinical rat model is unaffected by tamoxifen, 9cRA, and 4-HPR may actually have positive implications, because these agents are already in clinical use.
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