Words similar to tamoxifen

Example sentences for: tamoxifen

How can you use “tamoxifen” in a sentence? Here are some example sentences to help you improve your vocabulary:

Endocrine therapy with the antioestrogen tamoxifen can mediate the downregulation of c- myc , culminating in cell cycle arrest [ 44 ] . Berns et al . [ 12 ] reported that 38% of patients with amplification of c- myc or with coamplification of c- myc and HER-2 / neu profited from endocrine therapy.
However, here we used the NMU-induced rat model of mammary carcinogenesis to show that the chemopreventive effect of tamoxifen and two retinoids is not associated with any consistent changes in TGF-β levels, at least as determined immunohistochemically.
At this time, however, we certainly cannot rule out the possibility that tamoxifen and retinoids may be having subtle effects on the TGF-β system at levels other than the regulation of TGF-β expression.
The NYT front story on these drugs points out that one of them, tamoxifen, is already approved as a treatment for preventing the recurrence of breast cancer, but now becomes the first drug ever approved for the prevention of cancer in those who've never had it.
We have shown that treatment of rats with tamoxifen or retinoids results in effective chemoprevention of mammary tumorigenesis, without any detectable effect on local expression of TGF-βs.