Words similar to tamoxifen
Example sentences for: tamoxifen
How can you use “tamoxifen” in a sentence? Here are some example sentences to help you improve your vocabulary:
Assuming that a rat weighs approximately 250 g and eats 10 g of chow each day, the equivalent human doses to those used in this study would be approximately 2.5 mg/day tamoxifen, 2 g/day 4-HPR, and 290 mg/day 9cRA.
The NYT front story on these drugs points out that one of them, tamoxifen, is already approved as a treatment for preventing the recurrence of breast cancer, but now becomes the first drug ever approved for the prevention of cancer in those who've never had it.
Furthermore, complex effects of tamoxifen on induction of TGF-β 2 in the plasma of patients with metastatic breast cancer have been described [ 24].
The different doses of tamoxifen and 4-HPR used in humans and rats probably reflect interspecies differences in pharmacokinetics.
In conclusion, we have shown that treatment of rats with tamoxifen or retinoids results in effective chemoprevention of mammary tumorigenesis, without any detectable effect on local expression of TGF-βs.