Words similar to talin

Example sentences for: talin

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Shortly thereafter, the model gained direct and strong experimental support from a structural analysis in which the membrane-proximal helices of the two subunits were found to clasp in a weak “handshake” that could be disrupted by talin or constitutively activating mutations (Vinogradova et al.
2000), but the importance of talin in integrin activation is particularly convincing since it has been confirmed by multiple laboratories (Vinogradova et al.
A molecular picture has emerged for integrin insideout activation where a cellular signal induces the conformational change of talin exposing its head domain allowing it to bind to the integrin β cytoplasmic tail.
These include SH3 domains (Src homology 3 domains, that bind to target proteins), MYTH4 (a domain of unknown function found in a few classes of myosins), a zinc-binding domain, a pleckstrin homology domain, FERM/talin (band 4.1/ezrin/radixin/moesin), GPA-rich domains and a protein kinase domain [ 8, 22, 26].
Structures of the integrin cytoplasmic face bound to talin and the many other proteins known to bind to the cytoplasmic tails of integrins will undoubtedly provide further insights.