Example sentences for: talin

How can you use “talin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Structures of the integrin cytoplasmic face bound to talin and the many other proteins known to bind to the cytoplasmic tails of integrins will undoubtedly provide further insights.

  • These include SH3 domains (Src homology 3 domains, that bind to target proteins), MYTH4 (a domain of unknown function found in a few classes of myosins), a zinc-binding domain, a pleckstrin homology domain, FERM/talin (band 4.1/ezrin/radixin/moesin), GPA-rich domains and a protein kinase domain [ 8, 22, 26].

  • A molecular picture has emerged for integrin insideout activation where a cellular signal induces the conformational change of talin exposing its head domain allowing it to bind to the integrin β cytoplasmic tail.

  • Shortly thereafter, the model gained direct and strong experimental support from a structural analysis in which the membrane-proximal helices of the two subunits were found to clasp in a weak “handshake” that could be disrupted by talin or constitutively activating mutations (Vinogradova et al.

  • 2000), but the importance of talin in integrin activation is particularly convincing since it has been confirmed by multiple laboratories (Vinogradova et al.


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