Words similar to t-ra-
Example sentences for: t-ra-
How can you use “t-ra-” in a sentence? Here are some example sentences to help you improve your vocabulary:
Together these observations show that line A is poorly sensitive to T-RA-induced growth arrest and retains an essentially undifferentiated morphology, while growth of line B slows after 4-6 days of T-RA treatment and morphological differentiation is retarded.
However after 48 hours, there was a T-RA-dependent reduction in the amount of RARγ2 and TBP and a significant shift in the electrophoretic mobility of TAF II 135 (lanes 3-4).
Our results rather indicate that ectopic TAF II 135 expression acts at an early stage to impair primitive endoderm differentiation, but does not prevent the T-RA-induced changes which render the cells bt 2 cAMP responsive.
As the RARβ2 gene is important for T-RA-induced growth arrest [ 64], its delayed induction in lines A and B may in part explain the phenotype of these cells.
We show here that T-RA-induced primitive endoderm differentiation is impaired in cell lines constitutively expressing ectopic TAF II 135(372-1083) as judged from, retarded targeted degradation of RARγ2, cell morphology, growth inhibition, apoptotic response, and induction of the RARβ2 marker gene.