Words similar to sα
Example sentences for: sα
How can you use “sα” in a sentence? Here are some example sentences to help you improve your vocabulary:
When the 35 amino acid sequence was fused to the C-terminus of GFP (GFP-sα i2 35aa), this unique sα i2 sequence failed to direct GFP to intracellular membranes (Figure 5B); GFP-sα i2 35aa was diffusely distributed throughout the cytoplasm and nucleus, similar to what is observed for GFP alone (Figure 5A).
Thus, it is more likely that indeed sα i2 is deficient in binding to βγ, but this effect is a consequence of its instability.
Third, even though βγ can promote PM localization of sα i2 in the overexpression system described here, sα i2 remains less stable than α i2 (Figure 9), suggesting that such instability may also impair productive interactions with GPCRs.
Consistent with this idea, sα i2 was refractory to stable expression even though cells stably expressing α i2 were easily selected (not shown).
This is essential since suitable antibodies to detect and immuno-isolate sα i2 are not readily available.