Words similar to sα
Example sentences for: sα
How can you use “sα” in a sentence? Here are some example sentences to help you improve your vocabulary:
sα i2 shows a dramatic change in localization when co-expressed with βγ (Figure 8D), displaying strong PM staining.
Thus, the second possibility is that failure of sα i2 to localize at the PM but instead localize at intracellular membranes is the result of a general defect in protein stability.
The following results support this hypothesis: 1) sα i2 and α i2 are equally labeled by a pulse of 3H-myristate, although much less sα i2 protein is detected; 2) sα i2 displays a propensity to localize to potential aggresome-like structures, and this localization is greatly enhanced by proteasome inhibitor treatment; 3) the α i2 A327S mutant, previously shown to be unstable and defective in guanine-nucleotide binding, shows a similar pattern of subcellular localization ( i.e., intracellular membranes rather than PM); 4) βγ over-expression increases expression of sα i2 and promotes PM localization of sα i2 and α i2 A327S, but βγ co-expression does not prevent sα i2 localization to potential aggresome-like structures when cells are treated with proteasome inhibitors; and 5) pulse-chase analysis indicates that sα i2 is rapidly degraded.
In spite of its unknown functional significance, sα i2 provides a potential model for studying mechanisms of subcellular localization of Gα.
This is essential since suitable antibodies to detect and immuno-isolate sα i2 are not readily available.
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