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How can you use “sα” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • i2 shows a dramatic change in localization when co-expressed with βγ (Figure 8D), displaying strong PM staining.

  • Thus, the second possibility is that failure of i2 to localize at the PM but instead localize at intracellular membranes is the result of a general defect in protein stability.

  • The following results support this hypothesis: 1) i2 and α i2 are equally labeled by a pulse of 3H-myristate, although much less i2 protein is detected; 2) i2 displays a propensity to localize to potential aggresome-like structures, and this localization is greatly enhanced by proteasome inhibitor treatment; 3) the α i2 A327S mutant, previously shown to be unstable and defective in guanine-nucleotide binding, shows a similar pattern of subcellular localization ( i.e., intracellular membranes rather than PM); 4) βγ over-expression increases expression of i2 and promotes PM localization of i2 and α i2 A327S, but βγ co-expression does not prevent i2 localization to potential aggresome-like structures when cells are treated with proteasome inhibitors; and 5) pulse-chase analysis indicates that i2 is rapidly degraded.

  • In spite of its unknown functional significance, i2 provides a potential model for studying mechanisms of subcellular localization of Gα.

  • This is essential since suitable antibodies to detect and immuno-isolate i2 are not readily available.


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