Words similar to susceptibility
Example sentences for: susceptibility
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T1DM susceptibility in the NOD mouse is linked to I-A g7, the murine MHC class II gene that encodes a histidine at position 56 and a serine at position 57 in the β chain, in place of the more frequent proline 56β and aspartic acid 57β [ 3 ] . The development of diabetes is prevented in NOD.PD mice (which are NOD mice with I-A g7) that carry a β chain transgene with site-specific mutations that restore proline and aspartic acid at positions 56β and 57β, respectively [ 4 ] . Furthermore, because of the two amino acid changes in the additional (transgenic) MHC class II allele β chain in NOD.PD mice, NOD.PD mice recognize three additional peptide epitopes in the glutamic acid decarboxylase 65 (GAD65) autoantigen [ 5 ] .
Further, this implies that putative Ch6p alleles associated with CVID or IgGSD susceptibility occur on many HLA haplotypes that are common in Caucasians in central Alabama [ 10 ] and in Caucasians from a large national bone marrow donor program [ 14 ] . The present observations also confirm and extend the reports of association of HLA haplotype A*01-B*08 (or an extended haplotype containing A*01 and B*08) with heritable forms of immunoglobulin deficiency demonstrated in family-based analyses [ 3 6 19 20 21 22 ] . It is likely that a candidate gene(s) for CVID or IgGSD exists in the HLA class II region, [ 6 19 20 21 22 23 ] . Because the class II region is closer to the HLA-B locus than to the HLA-A locus, it is plausible that candidate gene(s) for CVID or IgGSD in the class II region are in greater linkage disequilibrium with HLA-B than HLA-A.
Alternatively, IFNγ may increase the expression of the death domain containing TNF-RI and thus increase the luteal endothelial cell death susceptibility upon exposure to TNFα.
Several population studies have documented a link between diabetes and senile cataract formation in persons aged 65 years and younger [ 21 22 23 24 25 26 ] . Conversely, a number of studies have shown little association of nuclear cataracts with diabetes [ 27 28 29 ] . Though this relationship continues to be debated, as are the underlying physiological mechanisms, premature opacification may occur due to an increased susceptibility to oxidative damage.
Equally important, gradual impairment of blood flow that nourishes tissues can lead to peripheral vascular disease, increased susceptibility to infection, cognitive decline, frailty, and other changes that impair life quality and longevity.
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