Words similar to surface-bound
Example sentences for: surface-bound
How can you use “surface-bound” in a sentence? Here are some example sentences to help you improve your vocabulary:
To acquire an equivalent density of surface-bound PG-1 molecules, B. cepacia needed exposure to much higher concentrations of PG-1 than P. aeruginosa . Thus, it is a reasonable inference that the relative resistance of B. cepacia to PG-1 is a consequence of the smaller number of protegrin molecules bound per unit area of bacterial surface.
An early study on DNA microarray hybridization found that hybridization was strongly dependent on the rate constants for DNA adsorption/desorption in the non-probe covered regions of the surface, the two-dimensional diffusion coefficient, and the size of probes and targets and also suggested that sparse probe coverage may provide results equal to or better than those obtained with a surface totally covered with DNA probes [ 19 ] . A theoretical analysis of the kinetics of DNA hybridization demonstrated that diffusion was important in determining the time of required to reach equilibrium and was proportional to the equilibrium binding constant and to the concentration of binding sites [ 20 ] . A recent theoretical and experimental analysis of competitive hybridization in a two-color system demonstrated the need for the hybridization kinetics of the two probes to be the same [ 21 ] . An elegant study on the use of hybridization kinetics to differentiate specific from non-specific binding was recently published [ 22 ] . This study found that the hybridization kinetics for specific and non-specific binding of labeled cRNA to surface-bound oligodeoxyribonucleotides were significantly different, with specific binding requiring longer to reach hybridization equilibrium than non-specific binding.
We note that the three-dimensional Codelink arrays used in this study are different from standard surface-bound arrays, and, therefore, it is not unexpected that the observations presented in this report are different from those generated on other array platforms.
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