Words similar to superantigen

Example sentences for: superantigen

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To determine whether costimulation through human CD81 affected these early activation events, peripheral blood cells from normal CMV seropositive donors were incubated for 6 h with a superantigen, SEB, or the viral antigen, CMV, in the presence or absence of an agonistic anti-CD81 mAb, 5A6.
As seen in Figure 1, over a range of antigen or superantigen concentrations, the addition of 5A6 increased the number of CD69 +cells as well as the number of IL-2-producing cells, measured by intracellular staining.
For experiments examining cytokine production and CD69 induction, whole blood or PBMC were incubated with antigen or superantigen for 6 h at 37°C, with addition of 10 μg/ml Brefeldin A (Sigma) at 2 h.
The cells were stimulated either with plate-bound anti-CD3 mAb (coated as described above) or soluble SEB superantigen (Sigma, at 1 μg/ml final concentration), in the presence or absence of 5-10 μg/ml 5A6 anti-CD81 mAb (added only at the initiation of the culture).
Our results demonstrate that peptidoglycan, teichoic acid, LPS, and the staphylococcal superantigen staphylococcal enterotoxin A (SEA), when present in the osteoblast extracellular environment, do not induce TRAIL expression (Fig.