Example sentences for: sulindac

How can you use “sulindac” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This is evident when one evaluates the concentrations required to achieve anticancer, cytoprotective actions in vitro [ 19 21 25 26 27 ] . More recently in the Apc minmouse model of familial adenomatous polyposis, a condition with a massive induction of polyps in the gastrointestinal tract, green tea extracts reduced polyp load and potentiated the effects of sulindac, a cyclo-oxygenase inhibitor used to treat gastrointestinal cancer [ 32 ] . This further affirms the potential of this strategy in managing disorders characterized by epithelial cell death and transformation.

  • In contrast, to date no conflicting data have been published regarding the use of sulindac.

  • In fact, the study conducted by Torrance and colleagues [ 47 ] demonstrated that doses of sulindac (5 mg/kg) found to be ineffective as stand-alone chemotherapy in the Min/+ model became extremely potent when combined with an epidermal growth factor receptor kinase inhibitor.

  • [ 6 ] demonstrated that Min /+ mice at approximately 11 weeks of age possessed roughly 35-40 polyps and that treatment (starting at 11 weeks of age) for as little as 4 days with sulindac produced a 75% reduction in polyp number.

  • The NSAID sulindac has been shown to cause regression of colorectal adenomas of patients with hereditary forms of polyposis (Familial Adenomatous Polyposis (FAP) and Gardner's Syndrome) [ 17 18 19 ] and in sporadic colorectal adenomas [ 20 ] . In addition, case reports have demonstrated that indomethacin and sulindac were effective co-therapy agents in the treatment of desmoid tumours [ 21 22 ] . Finally, the inclusion either of indomethacin, naproxen or sulindac in the chemotherapy regiment of gastric carcinoma patients resulted in a significant increase in survival; 30 months versus 6 months when NSAIDs included in treatment regime [ 22 ] .


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