Words similar to sulindac
Example sentences for: sulindac
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While the evaluation of aspirin in the Min /+ model utilising a therapeutic regime is lacking, other NSAIDs (sulindac, flurbiprofen, piroxicam and celecoxib) have been shown to significantly reduce polyp numbers when administered using similar protocols [ 6 11 34 35 ] . In addition, three recent reports have demonstrated a lack of effect of aspirin as a chemopreventive agent in Min /+ mice [ 36 37 38 ] . Combined, these studies indicate that the Min /+ model is responsive to NSAIDs other than aspirin when provided as a treatment.
[ 6 ] demonstrated that Min /+ mice at approximately 11 weeks of age possessed roughly 35-40 polyps and that treatment (starting at 11 weeks of age) for as little as 4 days with sulindac produced a 75% reduction in polyp number.
This is evident when one evaluates the concentrations required to achieve anticancer, cytoprotective actions in vitro [ 19 21 25 26 27 ] . More recently in the Apc minmouse model of familial adenomatous polyposis, a condition with a massive induction of polyps in the gastrointestinal tract, green tea extracts reduced polyp load and potentiated the effects of sulindac, a cyclo-oxygenase inhibitor used to treat gastrointestinal cancer [ 32 ] . This further affirms the potential of this strategy in managing disorders characterized by epithelial cell death and transformation.
In fact, the study conducted by Torrance and colleagues [ 47 ] demonstrated that doses of sulindac (5 mg/kg) found to be ineffective as stand-alone chemotherapy in the Min/+ model became extremely potent when combined with an epidermal growth factor receptor kinase inhibitor.
In contrast, to date no conflicting data have been published regarding the use of sulindac.
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