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Example sentences for: sulindac
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[ 6 ] demonstrated that Min /+ mice at approximately 11 weeks of age possessed roughly 35-40 polyps and that treatment (starting at 11 weeks of age) for as little as 4 days with sulindac produced a 75% reduction in polyp number.
This is evident when one evaluates the concentrations required to achieve anticancer, cytoprotective actions in vitro [ 19 21 25 26 27 ] . More recently in the Apc minmouse model of familial adenomatous polyposis, a condition with a massive induction of polyps in the gastrointestinal tract, green tea extracts reduced polyp load and potentiated the effects of sulindac, a cyclo-oxygenase inhibitor used to treat gastrointestinal cancer [ 32 ] . This further affirms the potential of this strategy in managing disorders characterized by epithelial cell death and transformation.
The NSAID sulindac has been shown to cause regression of colorectal adenomas of patients with hereditary forms of polyposis (Familial Adenomatous Polyposis (FAP) and Gardner's Syndrome) [ 17 18 19 ] and in sporadic colorectal adenomas [ 20 ] . In addition, case reports have demonstrated that indomethacin and sulindac were effective co-therapy agents in the treatment of desmoid tumours [ 21 22 ] . Finally, the inclusion either of indomethacin, naproxen or sulindac in the chemotherapy regiment of gastric carcinoma patients resulted in a significant increase in survival; 30 months versus 6 months when NSAIDs included in treatment regime [ 22 ] .
While the evaluation of aspirin in the Min /+ model utilising a therapeutic regime is lacking, other NSAIDs (sulindac, flurbiprofen, piroxicam and celecoxib) have been shown to significantly reduce polyp numbers when administered using similar protocols [ 6 11 34 35 ] . In addition, three recent reports have demonstrated a lack of effect of aspirin as a chemopreventive agent in Min /+ mice [ 36 37 38 ] . Combined, these studies indicate that the Min /+ model is responsive to NSAIDs other than aspirin when provided as a treatment.
In fact, the study conducted by Torrance and colleagues [ 47 ] demonstrated that doses of sulindac (5 mg/kg) found to be ineffective as stand-alone chemotherapy in the Min/+ model became extremely potent when combined with an epidermal growth factor receptor kinase inhibitor.
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