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Example sentences for: suggested
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It has been reported before that an increased excretion of orotate in sick children may not be uncommon and that a positive allopurinol load test may indicate unrecognized mitochondrial disease, making orotic acid as a potential marker of mitochondrial dysfunction [ 35 ] . A potential link between mitochondrial cytopathies and urea cycle dysfunction has also been suggested by the findings of hypocitrullinemia in patients with neurogenic weakness, ataxia and retinitis pigmentosa (NARP) syndrome (Mendelian Inheritance in Man database *551500) caused by a T8993G mutation in mtDNA that triggers ATPase deficiency [ 36 37 ] . It was hypothesized that the NARP mutation would cause complex V deficiency in the small intestine as well, thus reducing the availability of mitochondrial ATP required for citrulline synthesis.
Since differences in brain weight have been shown to be proportional to total brain DNA content and thus total CNS cell number [ 31 32 ] , and since brain weight has been suggested to be a good surrogate measure for total cell number in mice (as in humans [ 28 ] ), we hypothesize that total cell number - particularly in cortex - may be decreased in microgyric subjects.
[ 10 ] A vast series of pre-clinical and clinical studies have suggested 5-FU is a more active anti-tumor agent when modulated by a host of compounds including leucovorin, [ 11 12 13 ] methotrexate, [ 14 ] folinic acid, [ 15 16 ] N-phosphonacetyl-L-aspartic acid (PALA) [ 17 18 19 20 21 22 ] and recombinant interferon alfa-2a (IFNaα-2a).
Recently, altering the redox state of pulmonary artery endothelial cells in culture suggested that activation of redox-sensitive transcription factor activator protein-1 during hypoxia may be responsible for the increase in eNOS expression [ 22].
This arrangement suggested that there was a circular permutation with respect to the classical NlpC/P60 module in these proteins.
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