Words similar to substituents
Example sentences for: substituents
How can you use “substituents” in a sentence? Here are some example sentences to help you improve your vocabulary:
On the basis of observations [ 12 13 ] discussed above, one would expect AppppA with two phosphorothioadenosyl substituents to be a slow substrate with a relatively low K m . However, carbon in place of the β phosphorus (for example in 6b ) would make the leaving group the alkoxide - OCH 2 -CH(OH)-CH 2 O-phosphorothioadenosyl rather than α-thio ATP.
The lack of an aldehyde group on the periphery of the macrocycle of Chl c, which replaces Chl b in homologous complexes in chromophytic algae, indicates that the primary interaction between Chls and the proteins does not involve such substituents.
The F158A mutant exhibited higher K m values when using the cephalosporins as substrates, suggesting an interaction of the cephalosporins' substituents with the phenylalanine on the loop that extends over the active site.
E.-coli -expressed pR has post-translational modifications, including ~4000 daltons of substituents at one or more of its three cysteines.
All crystallographically characterized metallo-β-lactamases have a flexible amino acid chain that extends over the active site [ 37 42 44 45 46 47 48 49 ] . Previous NMR studies on CcrA have shown that this loop "clamps down" on substrate or inhibitor upon binding, and there is speculation that the distortion of substrate upon clamping down of the loop may drive catalysis [ 50 ] . The crystal structure of L1 showed that there is a large loop that extends over the active site, and modeling studies have predicted that two residues, Ile164 and Phe158, make significant contacts with large, hydrophobic substituents at the 2' or 6' positions on penicillins, cephalosporins, or carbapenems [ 37 ] . To test this prediction, Ile 164 and Phe158 were changed from large, hydrophobic residues to alanines to afford the I164A and F158A mutants.
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