Example sentences for: subpopulations

How can you use “subpopulations” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Stimulation with LPS in vitro produced an increase in TTP expression in all leukocyte subpopulations.

  • Specific macrophage subpopulations are associated with different tissues (alveolar macrophages in the lung, microglial cells in the central nervous system, etc.).

  • 2A,2B,2C; Table 1), consistent with the normal percentages and cell numbers for these subpopulations previously reported [ 29 ] . Recent papers by Penit, et al.

  • Loss of neuronal subpopulations integral to suckling need to be explored in the RU486 late gestation pups, but the data suggest that the health of this population is not directly influenced by altered GC response.

  • It is known that during clonal selection in the thymus, immature CD4, CD8 double positive cells develop into single positive CD4 or CD8 cells according to the relative affinity of their TCR to class II or class I molecules respectively [ 5 6 ] . These immature T-cells are selected in the thymic epithelium on the basis of their TCR interaction with either class I or class II MHC molecules [ 7 8 ] , thus generating two mutually exclusive subpopulations that are characterized by the expression of either CD4 or CD8 glycoproteins [ 9 ] . Earlier studies in the murine system have demonstrated that PMA and cAMP can modulate the expression CD4 and CD8 on developing thymocytes [ 10 11 12 13 ] . In keeping with these findings, ex vivo experiments with human thymocytes previously reported by our group, revealed that while phorbol esters can coordinately regulate the transcription of α and β TCR during intrathymic T cell differentiation [ 14 ] , cAMP selectively affected the transcription of the α and δ-TCR [ 15 16 ] . Together the murine data and our own findings support the hypothesis that in humans, TCR expression and CD4, CD8 commitment and selection may be regulated by the same signal-transduction pathways.


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