Words similar to subjacent
Example sentences for: subjacent
How can you use “subjacent” in a sentence? Here are some example sentences to help you improve your vocabulary:
The epithelial component of normal and non-invasive breast tissues is normally surrounded by a layer of myoepithelial (ME) cells, whose absence or disruption is an absolute prerequisite for tumor invasion and metastasis [ 1 ] . ME cells are not easily identifiable in hematoxylin/eosin (H&E)-stained breast tissue sections, as they are often indistinguishable from subjacent myofibroblastic cells in the stroma.
Our recent studies have revealed the co-localization of maspin and WT-1 exclusively in mammary ME cells [ 12 ] . In a vast majority of cases, the expression of these two proteins decreases linearly with tumor progression, and the loss of these proteins or focal disruptions in the ME cell layers leads to a significantly higher cell proliferation in the subjacent epithelial cells [ 12 33 ] . In addition, these changes in ME cells could result from effects of certain chemical compounds.
Our assumption is in agreement with our previous findings, which have revealed that focal disruptions of ME cell layers could lead to a significantly higher proliferation rate in subjacent epithelial cells [ 12 33 ] . Our assumption is also supported by a recent study showing that normal and tumor-derived ME cells differ substantially in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition [ 37 ] . Further studies are currently in progress to elucidate the biological behavior and genetic profile of epithelial cells immediately subjacent to these SMA-negative ME cells.
It has been documented that a variety of proteolytic enzymes produced by malignant epithelial cells could have substantial impacts on the physical integrity or functions of the subjacent ME cells and the basement membrane [ 30 31 32 ] . In contrast, ME cells could influence the biological behavior of subjacent epithelial cells.
This holds because if r N and r S are the reflectances of the RNFL and the subjacent structures, respectively, and t N is the transmission of the RNFL, then the net reflectance of the retina (both layers combined) will be:
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