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Example sentences for: subdomains
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These critical residues lie close to the γ-phosphate site in other AAA proteins with known structures and they are believed to trigger a change in the angle between the N- and C-subdomains of the protomer upon binding of ATP or dissociation of the γ-phosphate [ 18 ] . Indirect evidence suggests that such a conformational change in one protomer can be communicated to the adjacent protomers and result in a cooperative alteration in the shape of the overall hexameric ring [ 19 ] .
Although MHCK-A has been extensively characterized at the biochemical level [ 18 22 25 31 ] , only limited biochemical analysis has been performed with bacterially-expressed subdomains of MHCK-B and MHCK-C [ 17 18 22 ] . The current biochemical results provide strong support for the hypothesis that MHCK-C acts as a MHC kinase in vivo.
The sequence identity within the HisRS domain of IfkA/B and yeast GCN2 is 28%, with strong conservation within the M1, M2, and M3 motifs that are characteristic of class II aminoacyl-tRNA synthetases [ 37 ] . The similarity between the kinase domains is much higher, with IfkA/B possessing 44% identity with yeast GCN2, with high conservation of all of the kinase subdomains.
In transfected cells, subdomains of TAF II 135 can act as dominant negative repressors of CREB activity [ [ 26 27 28 ] ]. It has further been suggested that some neurodegenerative diseases may result from sequestration of TAF II 135 by expanded polyglutamine domains and consequent interference with CREB activity [ 29].
Based on these results, we propose a model for the relaxation of supercoiled DNA by E. coli topoisomerase I (Figure 7) modified from previous versions that have a number of common features but differ most significantly in the role of the Zn(II) binding domain [ 2 4 21 29 30 ] . In this model, the subdomains in Top67 is responsible for interacting with the G-strand of DNA both upstream and downstream of the cleavage site.
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