Words similar to subdomains

Example sentences for: subdomains

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To this end, two peptides were synthesized and purified based on selected sequences in the subdomains of human nmt55/p54 nrb(Figure 1A).
Although MHCK-A has been extensively characterized at the biochemical level [ 18 22 25 31 ] , only limited biochemical analysis has been performed with bacterially-expressed subdomains of MHCK-B and MHCK-C [ 17 18 22 ] . The current biochemical results provide strong support for the hypothesis that MHCK-C acts as a MHC kinase in vivo.
These critical residues lie close to the γ-phosphate site in other AAA proteins with known structures and they are believed to trigger a change in the angle between the N- and C-subdomains of the protomer upon binding of ATP or dissociation of the γ-phosphate [ 18 ] . Indirect evidence suggests that such a conformational change in one protomer can be communicated to the adjacent protomers and result in a cooperative alteration in the shape of the overall hexameric ring [ 19 ] .
In principle, more variability would be permitted for residues in subdomains III, VIII and IX which play a structural role but are not in direct contact with either ATP or the protein substrate.
Residues in subdomains VIB and VII are directly involved in catalysis and only the most conservative substitutions would be consistent with enzymatic activity.