Words similar to subdomains
Example sentences for: subdomains
How can you use “subdomains” in a sentence? Here are some example sentences to help you improve your vocabulary:
It has been suggested that the stability of the dimer is related to the buried surface area between the two subunits [ 11 12 ] . In the nevirapine-bound HIV-1 RT crystal structure, the total contact surface area between the subunits is approximately ~4600 Å 2. The two major contact regions between the subunits which provide it stability are their connection subdomains and the thumb of p51 and RNase H domain of p66.
This includes the characteristic features peculiar to the kinase domain of GCN2 proteins, the m1, m2, and m3 motifs of the HisRS domain, and a cluster of positively charged residues at the C-terminus that are thought to function in ribosome binding and dimerization [ 31 37 41 ] . Within the kinase domain, the Dictyostelium proteins possess an inserted sequence between the 4th and 5th kinase subdomains that is also found in this position in all known GCN2-like proteins.
These critical residues lie close to the γ-phosphate site in other AAA proteins with known structures and they are believed to trigger a change in the angle between the N- and C-subdomains of the protomer upon binding of ATP or dissociation of the γ-phosphate [ 18 ] . Indirect evidence suggests that such a conformational change in one protomer can be communicated to the adjacent protomers and result in a cooperative alteration in the shape of the overall hexameric ring [ 19 ] .
Although MHCK-A has been extensively characterized at the biochemical level [ 18 22 25 31 ] , only limited biochemical analysis has been performed with bacterially-expressed subdomains of MHCK-B and MHCK-C [ 17 18 22 ] . The current biochemical results provide strong support for the hypothesis that MHCK-C acts as a MHC kinase in vivo.
The blasticidin resistance cassette replaced a 391 bp fragment that includes the first four subdomains (the ATP binding site) of the kinase domain.
Loading...