Words similar to sub-lethal
Example sentences for: sub-lethal
How can you use “sub-lethal” in a sentence? Here are some example sentences to help you improve your vocabulary:
Sub-lethal radiation alone significantly reduced tumor volume (53%, p = 0.03), but the mice had a similar number of tumors (6.
However, in both intervention and regression trials, significant CD4 +T cell and CD8 +T cell infiltration into hyperplastic/dysplastic islets and tumors was noted in Rip1-Tag2 mice that had received the combination of sub-lethal radiation and adoptive transfer of TCR splenocytes.
Previous studies have shown that adoptively transferred tumor antigen-specific CD4 +T cells can be tolerized in the secondary lymphoid organs [ 9 34 ] , including the RIP-Tag2 model [ 30 ] . Radiation may kill or disable regulatory T cells [ 35 36 ] , or other bone marrow-derived tolerizing cells and prevent the induction of tolerance in adoptively transferred tumor-specific T cells [ 9 ] . Additionally, the high but sub-lethal dose of radiation used leads to significant lymphopenia [ 37 ] . The sudden reduction in lymphocyte number may create the spatial allowance in spleen and lymph nodes necessary for the homing, activation and expansion of he adoptively-transferred T cells.
Second, radiation-induced damage or abnormality may induce a "tissue damage signal" in the solid tumors through radiation-mediated apoptosis [ 38 ] . There is mounting evidence that apoptotic cell death is not immunologically benign, but can trigger immune responses [ 39 40 ] . For example, cells treated with ultraviolet radiation can provide potent adjuvant function in vivo [ 41 ] . Sub-lethal radiation could result in altered expression of pro or anti-inflammatory chemokines [ 42 43 44 ] or increased expression of T cell co-stimlulatory molecules (i.e.
In contrast, sub-lethal radiation alone resulted in a significant reduction of tumor burden (63%, p = 0.01).
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