Words similar to sub-lethal
Example sentences for: sub-lethal
How can you use “sub-lethal” in a sentence? Here are some example sentences to help you improve your vocabulary:
The splenocytes were derived from T cell receptor transgenic mice that preferentially enhanced development of CD4 +T cells recognizing a peptide within the SV40 large T oncoprotein [ 28 ] . While the transfer of naive splenocytes from the TCR transgenic mice had no effect on tumor development, sub-lethal radiation prior to lymphocyte transfer resulted in significant reduction in tumor burden in both intervention and regression trials.
However, in both intervention and regression trials, significant CD4 +T cell and CD8 +T cell infiltration into hyperplastic/dysplastic islets and tumors was noted in Rip1-Tag2 mice that had received the combination of sub-lethal radiation and adoptive transfer of TCR splenocytes.
Second, radiation-induced damage or abnormality may induce a "tissue damage signal" in the solid tumors through radiation-mediated apoptosis [ 38 ] . There is mounting evidence that apoptotic cell death is not immunologically benign, but can trigger immune responses [ 39 40 ] . For example, cells treated with ultraviolet radiation can provide potent adjuvant function in vivo [ 41 ] . Sub-lethal radiation could result in altered expression of pro or anti-inflammatory chemokines [ 42 43 44 ] or increased expression of T cell co-stimlulatory molecules (i.e.
Sub-lethal radiation alone significantly reduced tumor volume (53%, p = 0.03), but the mice had a similar number of tumors (6.
Thus, even with substantial tumor burden, the combination of sub-lethal radiation and splenocyte transfer could stop tumor growth during the course of the study.
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