Words similar to styrene
Example sentences for: styrene
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Some of the most comprehensive and sophisticated human PBPKs have been developed to describe the pharmacokinetics of volatile toxic solvents such as toluene [ 32 44 45 ] , styrene [ 46 47 ] , and methyl chloride [ 48 ] . The most involved models incorporate several different fat and muscle compartments with different flows and allow for changes with time in the blood flows as the subject's exercise level varies [ 45 47 48 ] . These studies have also introduced a Bayesian approach to determine the population distribution of the PBPK parameters [ 45 47 ] . PKQuest cannot complete with these PBPKs for this class of solutes.
For extremely soluble solutes such as ethanol (Kbair = 1756), the expired gas concentration is dominated by exchange with the conducting airway and is almost independent of the alveolar concentration [ 63 65 ] . For gases of intermediate solubility, such as styrene (Kbair = 48) or toluene (Kbair = 18) the effect is less dramatic and has often been overlooked.
For solutes such as toluene [ 45 67 ] , styrene [ 47 ] and methoxyflurane [ 58 ] there is, at first glance, a peculiar asymmetry in the data that has caused some confusion: during uptake there is a large difference in the end tidal and arterial partial pressures, while, during washout, there is only a small or negligible difference.