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Example sentences for: studies
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This is in agreement with previous studies which demonstrate that EP 2 is expressed and highly regulated in uterine luminal epithelium cells by ovarian steroids during the peri-implantation period [ 5 21 34 35 ] . The change in level of the EP 2 receptor expression in the uterus may contribute to the increase in G S protein content and cAMP concentration in mid-gestation and the decrease at term [ 26 27 ] . Because the EP 2 receptor is a G S -coupled cAMP-stimulating receptor, the EP 2 receptor may participate in the physiological regulation of uterine relaxation during pregnancy and the transition into uterine contraction at the onset of the labor.
The results of cell culture and animal studies have shown that omega 3 polyunsaturated fatty acids (n-3 PUFAs) selectively killed cancer cells in vitro [ 1 ] . Furthermore, n-3 PUFAs incorporated into animal diets have reduced tumor growth rates in vivo [ 2 3 4 ] . The prevailing hypothesis for the reduction in tumor cell growth, in vitro or in vivo , by supplementing the diet with high levels of n-3 PUFAs has been that the incorporation of n-3 PUFAs into cell membranes of the tumor cells increased the susceptibility of the cells for lipid peroxidation and that the products of lipid peroxidation subsequently accumulated to cytostatic or cytotoxic levels [ 2 5 6 7 ] . It has also been reported that supplementing the diet of cancer xenograft bearing mice with n-3 PUFAs could increase the efficacy of edelfosine [ 8 ] , doxorubicin [ 9 ] , mitomycin [ 10 ] , cyclophosphomide and 5-fluorouracil [ 11 ] or irinotecan [ 12 ] against the tumor.
These studies suggest that the VDR gene locus is a genetic marker for both type 1 and type 2 diabetes.
Previous studies have shown that DT40 cells deficient for Btk and PLCγ2 have similar BCR signaling defects.
25 However, numerous studies document that physicians generally fail to diagnose alcohol problems unless a formal screening protocol is used.
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