Words similar to striatum

Example sentences for: striatum

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Approximately 90% of all neurons in the striatum - 1.5 to 2.5 million in mice [ 1, 2] and 110-200 million in humans [ 3, 4] - belong to an unusual type 'of inhibitory projection cell referred to as medium spiny neurons [ 5 6 7 8 ] . Striatal neurons are divided into two major subpopulations (patch and matrix), that have somewhat different gene expression profiles and have different patterns of pre- and postsynaptic connections [ 9 10 11 12 13 ] .
3 [ 43 ] . Methylphenidate, the primary stimulant used in pharmacological treatment of ADHD, was shown by PET imaging to block the dopamine transporter [ 44 ] . ADHD patients have also been found to show higher levels of DAT1 in the striatum [ 45 ] . The most well studied polymorphism is a VNTR in the 3' untranslated region of the DAT gene [ 46 ] . Since this VNTR is not in the coding region of the DAT gene, it does not affect the protein sequence of the dopamine transporter, but may affect the translational efficiency and thus the amount of protein expressed.
Based on these findings, we anticipated significant differences in the striatum of inbred strains.
This result indicates that at least for the striatum, volume is not a reliable indicator of neuron number, and that they may be two independent traits.
To confirm and refine our genetic dissection of the striatum we plan to analyze the AXB and BXA recombinant inbred (RI) strains generated by crossing A/J with C57BL/6J.