Words similar to streptococcal
Example sentences for: streptococcal
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Previous studies have demonstrated that the inactivation of the sagA/pel gene product also effects expression of other key streptococcal products, including surface M proteins, streptokinase (SK) and the secreted cysteine protease, SpeB [ 4 ] . Analysis of SpeB, SK and M and M-related proteins was conducted to determine if restoration of the expression of the large sagA/pel transcript also reverted the other phenotypes associated with the wild type organism.
Streptococcus pyogenes causes a variety of diseases in man ranging from mild suppurative throat and skin infections like pharyngitis and erysipelas to severe invasive conditions such as necrotizing fasciitis and streptococcal toxic shock syndrome [ 1 ] . One of the most widely recognized putative streptococcal virulence factors is the oxygen-stable hemolysin, streptolysin S (SLS).
An increased mutans streptococcal challenge accompanying low plaque pH (high antibody response to D-alanyl LTA) allows much of the variation in caries experience to be controlled by water fluoridation and by the use of fluoridated dentrifices associated with maintaining oral health.
The precise biological role of SLS in streptococcal infections remains controversial [ 7 ] . The original analysis of the sagA gene demonstrated that inactivation of the gene encoding the polypeptide component of SLS rendered the organism less virulent in a dermonecrotic mouse model [ 3 ] . In a related series of studies, Li et al also isolated a mutant that not only lacked SLS activity but also affected other phenotypes [ 4 ] . The additional phenotypes included surface M and M-related protein as well as the secreted cysteine protease, streptococcal pyrogenic exotoxin B, SpeB [ 4 ] . The disrupted gene was termed pel (pleotrophic effect locus).
These include the cell-wall hydrolases typified by the Pal protein from streptococcal phages [ 24, 25] and the amidase domain of the bacterial and kinetoplastid GSPS [ 26].
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