Words similar to straight-forward
Example sentences for: straight-forward
How can you use “straight-forward” in a sentence? Here are some example sentences to help you improve your vocabulary:
For example, exon-skipping mutations in the central region of the gene, exons 24-32, cause severe phenotypes or neonatal presentations [ 8 ] . But there are exceptions, only four of the many other mutations in this region cause severe phenotypes, while one mutation predicted to lead to skipping of exon 24 was found in a patient with classic MFS [ 5 ] . In contrast, most cysteine substitutions cause classic MFS with a high frequency of lens dislocation, although some patients in our study did not meet the Ghent criteria for diagnosis of MFS [ 9 ] . Amino-acid substitutions not disrupting disulfide bonds may be associated with fibrillinopathies other than MFS, although mutations in the calcium-binding consensus sequence have been reported in individuals with classic MFS [ 5 10 11 12 ] . It is clear from the studies reported so far, that genotype-phenotype correlations are not straight-forward for FBN1 mutations.
The CASP results indicate that structure prediction methods have matured to a point where they can be applied on a genome-wide scale, and that these structures can be used with novel but straight-forward approaches to annotate and understand function [ 54 55 60 61 ] . The resulting models and annotations, when combined with other genomic/proteomic data, including that from gene expression arrays [ 62 ] , genome-wide two-hybrid experiments [ 63 ] , and other proteomics studies [ 64 ] , will provide us with a dynamic picture of organismal structure, function, and evolution [ 65 ] .
While some of the combinations do not necessarily enhance the simple approach of using only 3-residue fragments with a straight-forward monte carlo procedure, the combination of using fragments and the 14-state model for making moves, with MC and GA search techniques for the sampling, shows a significant improvement, which we hope to demonstrate at CASP5 by further extending the preliminary studies described here.
The most straight-forward design would involve a large number of hosts, some vaccinated and some unvaccinated.
QIOs found that working with nursing home providers demands an approach that is as simple and straight-forward as possible.
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