Example sentences for: stereoisomers

How can you use “stereoisomers” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • When diadenosine 5',5"'-( P 1, P 2-methylene- P 3-thio)- P 1, P 3-triphosphate [ 17 ] was crystallized with wild-type and mutant Fhit, the α-phosphorothioate group was found in the mutant but not wild-type active site, suggesting that α-phosphorothioate inhibitors may be slow substrates [ 12 ] . Similarly, Frey and co-workers found that Fhit slowly cleaves both R p and S p stereoisomers of γ-( m -nitrobenzyl)-adenosine 5'- O -(l-thiotriphosphate) with modest and similar beneficial effects on K m as compared to the corresponding phosphate [ 13 ] .

  • It is a mixture of eight stereoisomers in equal amounts designated "dl" or all-rac tocopherol and does have antioxidant properties [ 4 ] . Thus, different forms of vitamin E can have different antioxidant properties as well as differences in their absorption, distribution, and metabolism [ 4 ] . There are also reports that some forms of vitamin E have activity against cancer cells in vitro [ 3 5 ] . For example, tocotrienol and vitamin E succinate are reported to have antiproliferative activity in human cancer cells whereas some forms of vitamin E are reported to induce apoptosis in cancer cell types but not in normal cell types [ 3 ] . Specifically, these apoptogenic forms include RRR-α-tocopheryl succinate and RRR-δ-tocopherol while the α, β, and γ tocopherol and acetate derivatives of tocopherol were not apoptogenic [ 3 ] . There are few reports on the use of vitamin E for treating tumorous cancers in vivo but the results are inconsistent [ 4 5 6 7 8 9 10 ] . It is therefore essential that the form of vitamin E used in any research study as well as the dosage and the mode of administration be defined.

  • The contribution of particular P-chiral phosphorothioate stereoisomers to inhibition has not been examined.


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