Example sentences for: stem

How can you use “stem” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Years of rigorous and careful research in animal models have documented that embryonic stem cells have great utility for scientific studies.

  • The abilities to self-replicate and to give rise to daughter cells that undergo an irreversible terminal differentiation are features of stem cells [ 14, 15].

  • Here we show that human neural stem cells have a similarly broad differentiation potential, and that specific in vitro culture conditions can divert neural stem-derived cells from neural lineages toward a fate with endocrine and endodermal characteristics.

  • For example, mouse embryonal stem (ES) cells with homozygous deletion of the PTEN gene exhibit increased anchorage-independent growth as compared to normal ES cells [ 12 ] . Similarly, transfer of a wild type PTEN gene into anchorage-independent human glioblastoma cells (which lack functional PTEN), results in their greatly reduced ability to form colonies in soft agar [ 4 5 6 ] . The interpretation of these latter findings, however, is complicated by the strong anti-proliferative effects of PTEN even in monolayer culture, which is consistently observed when the wild type version of this gene is introduced into PTEN-negative tumor cells [ 4 6 7 8 9 10 18 33 ] . Moreover, in human glioma and breast cancer cell lines, the ectopic expression of wild type PTEN leads to anoikis, which is apoptosis initiated by the disruption of cell matrix-interactions [ 23 34 35 36 ] .

  • Banks of stem cells, Varmus observed, would reduce the need for "fetal donors."


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