Words similar to steady-state
Example sentences for: steady-state
How can you use “steady-state” in a sentence? Here are some example sentences to help you improve your vocabulary:
The increase in the 'dynamic trajectory' of the phase-plane plot between peak calcium and peak pressure may relate to underlying changes in the steady-state force-calcium relationship as proposed by Hunter [ 10 ] .
To reduce APV pill burden and possibly improve tolerability of APV treatment, pharmacokinetic research efforts have been directed at combining APV with the PI ritonavir (RTV), which inhibits CYP3A4-mediated hepatic metabolism of APV, thereby enhancing plasma APV exposure [ 13 14 15 ] . The administration of RTV at the clinically sub-therapeutic dosage of 100 mg BID was found to boost APV plasma exposure to such a degree as to permit halving the APV daily pill burden from 16 to 8 capsules/day, in addition to maintaining the minimum plasma APV concentration (C min ) over 24 hours well above the 50% inhibitory concentrations (IC 50 ) of patient-derived HIV-1 isolates [ 15 ] . A pharmacokinetic study in 20 HIV-infected patients, PROF1004, showed that APV at the lower dosage of 600 mg BID combined with RTV 100 mg BID (APV600/RTV) resulted in a geometric mean steady-state APV C min (1.
Accordingly, the myristoylation results (Figure 6Aand 6B, lanes 5 and 6) strongly suggested that α i2 and sα i2 are translated equally well, as evidenced by similar levels of radiolabeled myristate incorporation during the labeling period, but sα i2 is more rapidly degraded, as seen by reduced steady-state levels of immunoprecipitated protein.
The inclusion of 100 μM ZnCl 2 in the assay buffer resulted in slightly lower values of K m and higher values for k cat [ 36 ] . The inclusion of higher concentrations of Zn(II) did not further affect the steady-state kinetic constants.
However, in L1, Asn233 is 14 Å away from the modeled position of the substrate β-lactam carbonyl [ 37 ] . To test the role of Asn233 in substrate binding, the Asn was changed to a leucine (N233L) and to an aspartic acid (N233D), and these mutants were characterized by using metal analyses, CD spectroscopy, steady-state kinetics, and pre-steady state kinetic studies.
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