Words similar to steady-state
Example sentences for: steady-state
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To reduce APV pill burden and possibly improve tolerability of APV treatment, pharmacokinetic research efforts have been directed at combining APV with the PI ritonavir (RTV), which inhibits CYP3A4-mediated hepatic metabolism of APV, thereby enhancing plasma APV exposure [ 13 14 15 ] . The administration of RTV at the clinically sub-therapeutic dosage of 100 mg BID was found to boost APV plasma exposure to such a degree as to permit halving the APV daily pill burden from 16 to 8 capsules/day, in addition to maintaining the minimum plasma APV concentration (C min ) over 24 hours well above the 50% inhibitory concentrations (IC 50 ) of patient-derived HIV-1 isolates [ 15 ] . A pharmacokinetic study in 20 HIV-infected patients, PROF1004, showed that APV at the lower dosage of 600 mg BID combined with RTV 100 mg BID (APV600/RTV) resulted in a geometric mean steady-state APV C min (1.
Steady-state kinetic assays were conducted at 25°C in 50 mM cacodylate buffer, pH 7.0, containing 100 μM ZnCl 2 on a HP 5480A diode array UV-Vis spectrophotometer at 25°C.
The reaction of wild-type L1 with nitrocefin under steady-state conditions at 10°C resulted in a rapid decrease in fluorescence followed by a rate-limiting return of fluorescence (Figure 3A).
Steady-state kinetics constants, K m and k cat , were determined by fitting initial velocity versus substrate concentration data directly to the Michaelis equation using CurveFit [ 36 ] . The reported errors reflect fitting uncertainties.
Since the pre-pulse was not sufficiently long for inactivation to reach steady-state, we are not certain whether the observed incomplete inactivation reflects a component of the γ 1 null Ca 2+current that inactivates extremely slowly or a "truly" non-inactivating component.
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