Words similar to statins
Example sentences for: statins
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It is generally accepted that the hydroxy acid form of statins are potent inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, an enzyme that plays a critical role in cholesterol metabolism, where they block substrate accessibility to HMG-CoA reductase, effectively subverting cholesterol levels of HDL [ 19 20 21 ] . In addition to lowering cholesterol, statins seem to have a number of additional effects, such as the nitric oxide-mediated promotion of new blood vessel growth [ 22 ] , protection against oxidative modification of low-density lipoprotein, as well as anti-inflammatory effects and a reduction in C-reactive protein levels [ 23 ] . All statins limit cholesterol biosynthesis by inhibiting the committed step in the biosynthesis of isoprenoids and sterols [ 24 ] .
And while such potential connections could be drawn for any number of molecules, Gandy and colleagues went on to test whether statins exert their effect on APP cleavage by interfering with the isoprenoid/Rho/ROCK1 pathway.
Even so, in 2002, one year after the publication of Adult Treatment Panel III [3], statins were reportedly used in only 19% of patient visits with established CHD or its equivalents, and the average rate was no higher than 50% among high-risk visits where a diagnosis of hyperlipidemia also was noted.
α-Secretase activation may explain how statins lower the risk for Alzheimer disease [69], since atorvastatin diminishes Aβ burden in plaque-forming transgenic mice [13].
Mortality benefits of statins has been attributed to lower lipid levels, but recent reports indicate that statins may reduce cardiovascular risk by other mechanisms, [ 6 7 ] and may also reduce cancer-related mortality [ 8 ] . Consensus is growing for statin use in all ESRD patients with atherosclerotic disease or diabetes [ 9 ] . If used this way, over 60% of all dialysis patients might be eligible for statins [ 10 ] . Despite an acceptable safety profile [ 6 11 ] , fewer than 10% of dialysis patients were prescribed statins according to USRDS and Canadian studies, [ 3 12 ] even in known coronary heart disease [ 13 ] .
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