Example sentences for: statin-activated

How can you use “statin-activated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • FTI-1, an inhibitor of farnesyl transferase also known as L-744,832 [59], mimicked and potentiated statin-activated shedding, presumably by blocking transfer of isoprenoid moieties to a Rho protein by farnesyl transferase, and thereby decreasing Rho activity.

  • To test whether statin-activated shedding might be attributable to a metabolite downstream of HMGCoA reductase, cells were treated with 1 μM simvastatin, 5 μM FTI-1, and a series of concentrations of mevalonic acid.

  • As predicted by this model, we observed that statin-activated shedding was abolished by adding mevalonate.

  • Y-27632 showed no effect on basal sAPP α release and blocked statin-activated sAPP α shedding (data not shown).

  • Our data using statins and PO localize the mediator of statin-activated shedding to the plasma membrane, upstream of endocytosis, as appears to be the case for PKC-activated shedding [36,63,64,65].


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