Example sentences for: statin-activated

How can you use “statin-activated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In our paper [2], we present evidence that the isoprenoid pathway contributes to statin-activated shedding of the APP ectodomain in cultured cells.

  • As predicted by this model, we observed that statin-activated shedding was abolished by adding mevalonate.

  • Low doses (<1 μM) of mevalonic acid did not affect statin-induced sAPP α shedding, but complete inhibition of statin-activated sAPP α shedding was achieved with higher doses of mevalonic acid (100 μM).

  • To test whether statin-activated shedding might be attributable to a metabolite downstream of HMGCoA reductase, cells were treated with 1 μM simvastatin, 5 μM FTI-1, and a series of concentrations of mevalonic acid.

  • FTI-1, an inhibitor of farnesyl transferase also known as L-744,832 [59], mimicked and potentiated statin-activated shedding, presumably by blocking transfer of isoprenoid moieties to a Rho protein by farnesyl transferase, and thereby decreasing Rho activity.


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