Example sentences for: statin-activated

How can you use “statin-activated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • To test whether statin-activated shedding might be attributable to a metabolite downstream of HMGCoA reductase, cells were treated with 1 μM simvastatin, 5 μM FTI-1, and a series of concentrations of mevalonic acid.

  • Our data using statins and PO localize the mediator of statin-activated shedding to the plasma membrane, upstream of endocytosis, as appears to be the case for PKC-activated shedding [36,63,64,65].

  • We recently excluded the possibility that either PKC or ERK plays a role in statin-activated shedding [16], raising the possibility that other protein phosphorylation signaling pathways might link statins and/or cholesterol to α-secretase activation.

  • In our paper [2], we present evidence that the isoprenoid pathway contributes to statin-activated shedding of the APP ectodomain in cultured cells.

  • In further support of a role for isoprenoids, we were able to demonstrate that supplementation of cells with mevalonate abolished statin-activated shedding (see Figure 4).


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