Words similar to stat
Example sentences for: stat
How can you use “stat” in a sentence? Here are some example sentences to help you improve your vocabulary:
The role of the coactivators could be just as bridging factors, although some of the members of the p160 family and CBP/p300 present histone acetyltransferase activity [ 34 35 ] . Stat3 is a member of the JAK/STAT signaling pathway, which is a transcription factor itself that after activation binds to specific sequences in DNA to regulate expression of genes related to proliferation, differentiation and cell survival.
Moreover, Stat3 has also been directly associated with several coactivators, such as SRC-1 and CBP/p300 [ 9 12 ] . Recruitment of coactivators to nuclear receptors takes place via a common motif in the coactivators containing a core consensus sequence LXXLL (L, leucine; X, any aminoacid) [ 38 ] . Most of the coactivators contain more than one of these motifs, raising the question regarding specificity of these motifs to specific activating domains in the nuclear receptors.
Several possible mechanisms have been suggested to explain this activation of AR, including mutations in the gene encoding AR that alter the specificity for androgens, overexpression of the AR protein itself, cross-talk to other signal transduction pathways, and altered levels or activity of coactivators [ 21 22 23 ] . Several groups including ours have demonstrated a role of activated Stat3 in the proliferation and survival of prostate cancer cells by a mechanism that involves the AR [ 24 25 26 27 28 ] .
The importance of STAT3 activation via IL-6 in prostatic cancer development has been suggested by previous investigators.
(110 Stat.
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