Words similar to ssitt
Example sentences for: ssitt
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[29], who documented in 14/25 (56%) SSITT patients the presence of minor populations of M184V occurring at least once off drug during interruption of therapy.
The largest study to date in this area is the prospective single-arm Swiss–Spanish Intermittent Trial (SSITT) conducted in 133 recruited patients undergoing sequential 2-wk TIs and showing a lack of impact of this strategy on achieving sustained viral loads of less than 5,000 copies/ml off therapy in those that completed the study [11].
Consistent with the findings of SSITT [11], analysis of our data by the categorical classification of a “responder” as a patient with viral load less than 5,000 copies/ml at week 12 off therapy showed no significant difference in this frequency between arms (single TI, 5/18; repeated TI, 5/16), suggesting the presence of “responders” irrespective of previous protocol-mandated TIs.
However, the percentage of patients with resistance mutations detected in this study in the repeated interruption arm (47%) is higher than the 17% observed in the SSITT cohort [11], in which patients with prior treatment failures were excluded [28].
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