Words similar to ssitt
Example sentences for: ssitt
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However, the percentage of patients with resistance mutations detected in this study in the repeated interruption arm (47%) is higher than the 17% observed in the SSITT cohort [11], in which patients with prior treatment failures were excluded [28].
[29], who documented in 14/25 (56%) SSITT patients the presence of minor populations of M184V occurring at least once off drug during interruption of therapy.
Consistent with the findings of SSITT [11], analysis of our data by the categorical classification of a “responder” as a patient with viral load less than 5,000 copies/ml at week 12 off therapy showed no significant difference in this frequency between arms (single TI, 5/18; repeated TI, 5/16), suggesting the presence of “responders” irrespective of previous protocol-mandated TIs.
The largest study to date in this area is the prospective single-arm Swiss–Spanish Intermittent Trial (SSITT) conducted in 133 recruited patients undergoing sequential 2-wk TIs and showing a lack of impact of this strategy on achieving sustained viral loads of less than 5,000 copies/ml off therapy in those that completed the study [11].