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Example sentences for: spo
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Presence of four introns suggested that the rec12 +cDNA encodes a protein of 345 amino acids with high homology to eukaryotic Spo11 proteins (Figure 1B).
It is dispensable for chromosome pairing and synapsis in some organisms, but is required in others [ 22 24 25 26 27 28 ] . Budding yeast spo11Δ (null) mutants lack chromosome pairing, but catalytic site tyrosine mutants ( spo11-Y135F ) support significant levels of DSB-independent pairing [ 29 ] , so the function of Spo11 proteins in pairing may be separable from its function in catalyzing recombination.
Rec12 (Spo11) protein shares homology with the catalytic (Top6A) subunit of Topoisomerase VI, which functions as a heterotetramer with Top6B [ 16 17 ] . However, no Top6B homolog is present in most eukaryotes and the Rec12 (Spo11) enzyme does not need to affect strand passage in the manner of canonical type II topoisomerases [ 11 ] . We therefore tested whether overexpression of rec12 +would lead to a hyper-recombination phenotype, thereby implicating function as a homodimer.
In support of this possibility, Spo11 of mice colocalizes extensively along homologously synapsed chromosomes during pachytene and dissociates when the homologs segregate from one-another during anaphase of MI [ 25 ] .
While rec12 +was reported to encode a protein of 139 amio acids [ 30 ] , conceptual translation of the surrounding region suggested that rec12 +encoded a larger protein with homology to Spo11 of S. cerevisiae and Top6A of Sulfolobus shibatae [ 17 21 ] . Alignments and splicing sequence profiles [ 31 ] were used to identify four putative introns (Figure 1A).
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