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Example sentences for: spo

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Identification of four introns (Figure 1) and complete complementation of the rec12-117 hyporecombination defect by the full-length cDNA (Figure 2) confirmed that Rec12 protein is homologous to Spo11 of other eukaryotes [ 11 ] . Both Rec12 and its active site tyrosine are required for intragenic and intergenic recombination at multiple locations on all three chromosomes (Figure 2, Tables 1, 2, data not shown).
This role for Rec12 in equational chromosome segregation may be conserved, as spo11 mutants of Sordaria macrospora also exhibit frequent MII nondisjunction (S.
Meiotically induced, Spo11 (Rec12)-dependent double-strand DNA (dsDNA) breaks have been demonstrated in budding yeast and fission yeast [ 12 13 14 15 ] . Spo11 almost certainly catalyzes these breaks, as it shares high homology with the A subunit of Topoisomerase VI of Sulfolobus shibatae [ 16 17 ] and it becomes linked by a phosphotyrosine linkage to the 5' end of the cleaved DNA [ 18 19 20 21 ] . Spo11 homologs have been identified in a wide range of eukaryotes, and available evidence suggests that initiation of meiotic recombination via Spo11-dependent dsDNA break formation is conserved [ 22 23 24 25 ] . Our results with the fission yeast S. pombe fully support this view (see results and discussion).
Conserved structure and function of Rec12 (Spo11) to initiate recombination
Spo11 protein has potential functions in addition to catalyzing dsDNA breaks.