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Example sentences for: spo

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This study examined the relationship between meiotic recombination and chromosome segregation in rec12 ( spo11 ) mutants of fission yeast.
While rec12 +was reported to encode a protein of 139 amio acids [ 30 ] , conceptual translation of the surrounding region suggested that rec12 +encoded a larger protein with homology to Spo11 of S. cerevisiae and Top6A of Sulfolobus shibatae [ 17 21 ] . Alignments and splicing sequence profiles [ 31 ] were used to identify four putative introns (Figure 1A).
Spo11 protein has potential functions in addition to catalyzing dsDNA breaks.
Rec12 (Spo11) protein shares homology with the catalytic (Top6A) subunit of Topoisomerase VI, which functions as a heterotetramer with Top6B [ 16 17 ] . However, no Top6B homolog is present in most eukaryotes and the Rec12 (Spo11) enzyme does not need to affect strand passage in the manner of canonical type II topoisomerases [ 11 ] . We therefore tested whether overexpression of rec12 +would lead to a hyper-recombination phenotype, thereby implicating function as a homodimer.
In support of this possibility, Spo11 of mice colocalizes extensively along homologously synapsed chromosomes during pachytene and dissociates when the homologs segregate from one-another during anaphase of MI [ 25 ] .