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Example sentences for: spo
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This study examined the relationship between meiotic recombination and chromosome segregation in rec12 ( spo11 ) mutants of fission yeast.
It is dispensable for chromosome pairing and synapsis in some organisms, but is required in others [ 22 24 25 26 27 28 ] . Budding yeast spo11Δ (null) mutants lack chromosome pairing, but catalytic site tyrosine mutants ( spo11-Y135F ) support significant levels of DSB-independent pairing [ 29 ] , so the function of Spo11 proteins in pairing may be separable from its function in catalyzing recombination.
Meiotically induced, Spo11 (Rec12)-dependent double-strand DNA (dsDNA) breaks have been demonstrated in budding yeast and fission yeast [ 12 13 14 15 ] . Spo11 almost certainly catalyzes these breaks, as it shares high homology with the A subunit of Topoisomerase VI of Sulfolobus shibatae [ 16 17 ] and it becomes linked by a phosphotyrosine linkage to the 5' end of the cleaved DNA [ 18 19 20 21 ] . Spo11 homologs have been identified in a wide range of eukaryotes, and available evidence suggests that initiation of meiotic recombination via Spo11-dependent dsDNA break formation is conserved [ 22 23 24 25 ] . Our results with the fission yeast S. pombe fully support this view (see results and discussion).
In support of this possibility, Spo11 of mice colocalizes extensively along homologously synapsed chromosomes during pachytene and dissociates when the homologs segregate from one-another during anaphase of MI [ 25 ] .
This provides evidence that a dimer of Rec12/Spo11 protein, harboring two functional active sites, is required for catalysis of dsDNA breaks in each organism.
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