Example sentences for: spiny

How can you use “spiny” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • 8A) and numerous spiny processes (full arrowhead).

  • Approximately 90% of all neurons in the striatum - 1.5 to 2.5 million in mice [ 1, 2] and 110-200 million in humans [ 3, 4] - belong to an unusual type 'of inhibitory projection cell referred to as medium spiny neurons [ 5 6 7 8 ] . Striatal neurons are divided into two major subpopulations (patch and matrix), that have somewhat different gene expression profiles and have different patterns of pre- and postsynaptic connections [ 9 10 11 12 13 ] .

  • The striatum may be a special case - a region in which numbers of medium spiny neurons is more tightly regulated than neuron populations in some other regions.

  • In the case of Huntington disease the loss of 15-30% of the normal complement of medium spiny neurons leads to distinct movement disorder in both humans and transgenic mouse models [ 14 15 16 17 ] . The subset of genes that normally control the proliferation, differentiation, and survival of striatal neurons [ 18 19 20 ] are therefore of considerable importance in ensuring adaptive behavior at maturity.

  • Numbers of medium spiny neurons and ratios of these and less numerous striatal interneurons are critical variables that influence motor performance and aspects of cognition.


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