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Example sentences for: spiny
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In the case of Huntington disease the loss of 15-30% of the normal complement of medium spiny neurons leads to distinct movement disorder in both humans and transgenic mouse models [ 14 15 16 17 ] . The subset of genes that normally control the proliferation, differentiation, and survival of striatal neurons [ 18 19 20 ] are therefore of considerable importance in ensuring adaptive behavior at maturity.
Picrothamnus was established by Nuttall, but reduced as A. spinescens Hall and Clements, and according to Bremer and Humphries [ 2 ] is essentially Dracunculus with two autapomorphies: spiny habit and cobwebby-pilose cypselas.
Approximately 90% of all neurons in the striatum - 1.5 to 2.5 million in mice [ 1, 2] and 110-200 million in humans [ 3, 4] - belong to an unusual type 'of inhibitory projection cell referred to as medium spiny neurons [ 5 6 7 8 ] . Striatal neurons are divided into two major subpopulations (patch and matrix), that have somewhat different gene expression profiles and have different patterns of pre- and postsynaptic connections [ 9 10 11 12 13 ] .
The striatum may be a special case - a region in which numbers of medium spiny neurons is more tightly regulated than neuron populations in some other regions.
César Manrique also cultivated the spiny flora into a beautiful Jardín de Cactus complete with a working windmill that produces its own gofio (see page 15).
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