Words similar to spindle
Example sentences for: spindle
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These ME cell layers were attenuated, consisting of elongated spindle cells with dark and compressed nuclei.
We tested if these spots were associated with the spindle pole body (SPB), given that an ultimate receiver of the checkpoint signal, Cdc2, resides at the SPB prior to mitosis in fission yeast [ 61 ] . However, these Rad26-GFP foci did not co-localize with a SPB marker, Sad1 (data not shown) [ 62 ] .
After replication, the chromosomes (now comprising two chromatids) align at the center of the cell, and are attached to a structure known as the spindle apparatus.
Abnormal chromosome segregation has been observed in mice lacking the Mad2 checkpoint protein [ 25 ] . The spindle checkpoint utilizes sensory proteins that detect kinetochore-microtubule tension and occupancy and transiently block anaphase until all of the chromosomes are properly attached to microtubules [ 16 26 27 ] . Although the mammalian spindle checkpoint appears to differ between mitosis and meiosis, the two meiotic divisions, and male and female germ cells [ 28 ] , anaphase subsequently follows stable kinetochore-microtubule attachments [ 17 29 ] in both vertebrate mitotic [ 30 ] and meiotic [ 31 ] cells.
It has been shown by others that compared to muscles in the cat hindlimb where spindle classification can be based almost entirely on conduction velocity, non-limb muscles contain primary and secondary muscle spindle afferents that are generally slower conducting and exhibit overlapping bimodal or unimodal conduction velocity spectra [ 12 13 ] . These studies have shown that only the very fastest afferents innervate primary endings (>75 m/s) and the negatively adapting discharge frequency during static hold and the abrupt decrease in firing at the end of static stretch are the best criteria for characterization of primary spindle afferents.
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