Words similar to spindle
Example sentences for: spindle
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Because the putative Tem1 antagonists and mitotic checkpoint proteins Bub2 and Bfa1 negatively regulate exit from mitosis and cytokinesis in response to both DNA damage and spindle misorientation ( [ 32 ] ; reviewed in [ 33 ] ), we asked whether bypass of TEM1 -dependent regulation can cause chromosome instability.
Physiological experiments can also be used to characterize heterochromatin-binding proteins [ 45 ] . For example, absence of Swi6 in fission yeast sensitizes cells to thiabendazole (TBZ), a microtubule depolymerizing drug [ 46 ] . Presumably this occurs because absence of Swi6 disrupts centromeric heterochromatin and, as a result, sensitizes cells to drugs that compromise spindle function.
Tem1 is thought to be kept inactive throughout early mitosis by the two-component GTPase-activating protein complex Bub2/Bfa1 which co-localizes with Tem1 at the spindle pole body [ 10 11 ] . When the mitotic spindle penetrates the mother-daughter neck, the Tem1-bound spindle pole body is translocated into the daughter cell where a cortical pool of Lte1 is thought to activate Tem1 [ 12 13 ] . In addition to this spatial regulation, the GTPase activity of Bfa1 is thought to be inactivated through its phosphorylation by Cdc5 [ 14 ] , but it remains unknown how this process is coordinated with the presumed juxtaposition of Lte1 and Tem1 in the daughter cell.
The stellate projections are clearly delineated even at their termini, and the cell bodies do not demonstrate a flattened, oval, or spindle phenotype.
Indeed, the kinetics of cell cycle progression (monitored by either elongation of the mitotic spindle or delocalization of Cdc14 from the nucleolus) in the wild-type and the net1(7m) mutant strains were almost identical (Figure 6C).
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