Words similar to spermatogenesis
Example sentences for: spermatogenesis
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The adult testis is a complex organ consisting of numerous different somatic cell types as well as germ cells at all stages of spermatogenesis from the gonocyte stem cells to the mature sperm cells [ 18 ] . Consequently, several unique gene populations, including those involved in the regulation of meiosis, as well as those specific to the various testicular cell types, are expressed in the testis.
The clinical criteria of male hypogonadism refers to failure of testicular function resulting in decreased production or absence of male sex hormones and impaired spermatogenesis, whether this failure is secondary to hypothalamic and pituitary dysfunction or is primary testicular failure [ 20].
, [ 10 12 13 14 15 ] ]. It is thought to regulate spermatogenesis and sperm maturation by maintaining high androgen levels in the testis and epididymis [ 16 17 ] and has been proposed as a biochemical marker for Sertoli cell function and formation of blood-testis barrier [ 12 18 ] . More recently, cell surface receptors for ABP and its liver-derived homolog sex hormone-binding globulin (SHBG) were identified in several androgen target tissues, suggesting that these extracellular steroid-binding proteins may have a much broader, hormone-like function [ 19 20 21 ] .
The late stages of spermatogenesis (spermiogenesis) were extensively studied for the possible direct effects of ABP [ 16 17 42 43 44 45 ] . In these studies, however, ABP (at least at physiological concentrations) appeared to be supportive, rather than detrimental, to spermatogenesis.
Our earlier findings including a reduced number of elongated spermatids in the ABP-TG mice [ 26 ] also support the notion that higher than physiological concentrations of ABP affect spermatogenesis indirectly, through sequestration of androgens; the transformation of round spermatids to elongated spermatids is known to be the main androgen-dependent step in spermatogenesis [ 35 36 37 ] .
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