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Example sentences for: spectrin
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Spectrin and protein 4.1 form a complex with actin filaments [ 17 26 ] that may be important in signaling in additional to forming a physical link between the cytoskeletal network and the cell membrane [ 27 ] . Furthermore, PI4K activity has been shown to associate with the actin cytoskeleton by biochemical detergent extraction [ 28 ] and is thought to specifically localize with α3β1 integrin [ 29 ] . PI4K catalyzes the production of phosphatidylinositol-4-phosphate, an intermediate in multiple phosphatidylinositol signaling pathways which itself can interact with actin binding proteins to regulate microfilament polymerization [ 30 ] . Our work now suggests that the mRNAs of these proteins are all positioned in close association with the actin cytoskeleton to permit efficient localization of their protein products.
CFEOM1 patient and normal muscle sections from extraocular muscle were stained with anti-human sarcospan and anti-human spectrin antibodies.
Interactions between spectrin and actin filaments are stabilized by protein 4.1 and regulated by a variety of accessory proteins [ 17 ] . Protein 4.1 also may connect the protein translation apparatus to the cytoskeleton through interactions with a component of the eukaryotic translation initiation factor-3 complex, eIF3-p44 [ 18 ] . Interestingly, mRNAs for multiple proteins involved in translation, such as various ribosomal proteins, were enriched in the cytoskeleton fraction (Table I).
Anti-human spectrin antibodies (NCL-SPEC1) were obtained from Vector Laboratories.
Selected transcripts identified by microarray analysis, including β-actin, spectrin and phosphatidylinositol-4-kinase (PI4K), were subsequently confirmed by semi-quantitative RT-PCR (Fig.
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