Words similar to spectrin
Example sentences for: spectrin
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CFEOM1 patient and normal muscle sections from extraocular muscle were stained with anti-human sarcospan and anti-human spectrin antibodies.
Among the subset of transcripts that were found to be enriched in the cytoskeleton fraction were several mRNA species, such as those encoding β-actin mRNA and ribosomal protein subunits, that have previously been shown to be cytoskeleton-associated in other cell types [ 13 16 ] . In addition, we identified approximately 20 new members of the cytoskeleton-associated transcriptome, the majority of which encode structural proteins known to interact directly with cytoskeleton filaments, such as spectrin and protein 4.1 (Table 1).
Interactions between spectrin and actin filaments are stabilized by protein 4.1 and regulated by a variety of accessory proteins [ 17 ] . Protein 4.1 also may connect the protein translation apparatus to the cytoskeleton through interactions with a component of the eukaryotic translation initiation factor-3 complex, eIF3-p44 [ 18 ] . Interestingly, mRNAs for multiple proteins involved in translation, such as various ribosomal proteins, were enriched in the cytoskeleton fraction (Table I).
Selected transcripts identified by microarray analysis, including β-actin, spectrin and phosphatidylinositol-4-kinase (PI4K), were subsequently confirmed by semi-quantitative RT-PCR (Fig.
There is some evidence which suggests that spectrin facilitates Golgi membrane association with motor proteins, including cytoplasmic dynein, kinesin and myosin [ 60, 61].
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