Words similar to spectrin
Example sentences for: spectrin
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CFEOM1 patient and normal muscle sections from extraocular muscle were stained with anti-human sarcospan and anti-human spectrin antibodies.
Selected transcripts identified by microarray analysis, including β-actin, spectrin and phosphatidylinositol-4-kinase (PI4K), were subsequently confirmed by semi-quantitative RT-PCR (Fig.
have previously monitored gene expression at various time points following phorbol ester-induced differentiation in the same HL-60 cell system [ 22 ] . Thirteen of the 22 transcripts we identified as cytoskeleton-associated were also assayed in that study by Tamayo, et al [ 22 ] . Only two of these transcripts-alpha spectrin and pim-1 were found to vary significantly, in that the expression of both genes was undetectable in the promyelocytic cell type and increased dramatically upon differentiation to the macrophage cell type.
Spectrin and protein 4.1 form a complex with actin filaments [ 17 26 ] that may be important in signaling in additional to forming a physical link between the cytoskeletal network and the cell membrane [ 27 ] . Furthermore, PI4K activity has been shown to associate with the actin cytoskeleton by biochemical detergent extraction [ 28 ] and is thought to specifically localize with α3β1 integrin [ 29 ] . PI4K catalyzes the production of phosphatidylinositol-4-phosphate, an intermediate in multiple phosphatidylinositol signaling pathways which itself can interact with actin binding proteins to regulate microfilament polymerization [ 30 ] . Our work now suggests that the mRNAs of these proteins are all positioned in close association with the actin cytoskeleton to permit efficient localization of their protein products.
Anti-human spectrin antibodies (NCL-SPEC1) were obtained from Vector Laboratories.
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