Example sentences for: spectrin

How can you use “spectrin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Domains with less significant E-values include six kinesins which contain spectrin repeats (1.

  • have previously monitored gene expression at various time points following phorbol ester-induced differentiation in the same HL-60 cell system [ 22 ] . Thirteen of the 22 transcripts we identified as cytoskeleton-associated were also assayed in that study by Tamayo, et al [ 22 ] . Only two of these transcripts-alpha spectrin and pim-1 were found to vary significantly, in that the expression of both genes was undetectable in the promyelocytic cell type and increased dramatically upon differentiation to the macrophage cell type.

  • Interactions between spectrin and actin filaments are stabilized by protein 4.1 and regulated by a variety of accessory proteins [ 17 ] . Protein 4.1 also may connect the protein translation apparatus to the cytoskeleton through interactions with a component of the eukaryotic translation initiation factor-3 complex, eIF3-p44 [ 18 ] . Interestingly, mRNAs for multiple proteins involved in translation, such as various ribosomal proteins, were enriched in the cytoskeleton fraction (Table I).

  • Spectrin and protein 4.1 form a complex with actin filaments [ 17 26 ] that may be important in signaling in additional to forming a physical link between the cytoskeletal network and the cell membrane [ 27 ] . Furthermore, PI4K activity has been shown to associate with the actin cytoskeleton by biochemical detergent extraction [ 28 ] and is thought to specifically localize with α3β1 integrin [ 29 ] . PI4K catalyzes the production of phosphatidylinositol-4-phosphate, an intermediate in multiple phosphatidylinositol signaling pathways which itself can interact with actin binding proteins to regulate microfilament polymerization [ 30 ] . Our work now suggests that the mRNAs of these proteins are all positioned in close association with the actin cytoskeleton to permit efficient localization of their protein products.

  • There is some evidence which suggests that spectrin facilitates Golgi membrane association with motor proteins, including cytoplasmic dynein, kinesin and myosin [ 60, 61].


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