Words similar to speckles

Example sentences for: speckles

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The mutated proteins are located in cytoplasmic speckles similar to the N346 NLSmut1and N346 NLSmut3(Fig 7B).
Mutations of the fourth site (R358S/K360T) within GFP-N346, GFP-N346 NLSmut4, do not change the nuclear localization of GFP-N346, but abolish the speckles (Fig 7B).
Objects in nuclei recognized by antibodies specific for phosphoprotein epitopes, cytoplasmic IFs, or both, have been reported in glial and neuronal cells, in situ and in vitro . The nuclear structures appear spherical or rod-like and may have a positional relationship with nuclear pores [ 1 2 3 4 ] . Morphologically, these structures appear similar to the nuclear "speckles" that are thought to be storage sites for RNA splicing factors [ 5 6 7 ] . However, while intermediate filament (IF) phosphoproteins could be components of nuclear speckles, they are immunologically distinct.
Nearly all nuclei (95%) contained small, numerous Rad26-GFP speckles, and roughly 50% of these nuclei also contained one or two very bright Rad26-GFP spots.
A mutant allele, rad26.T12 , genetically separates these functions, since rad26.T12 cells can undergo checkpoint-induced cell cycle arrest but fail to recover and lose viability [ 13 40 ] . To determine if spots and speckles are associated with these different Rad26 functions, we tagged the C-terminus of Rad26.T12 with GFP using the same primers and method that we used to tag Rad26 (see Methods).