Words similar to speckles
Example sentences for: speckles
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Objects in nuclei recognized by antibodies specific for phosphoprotein epitopes, cytoplasmic IFs, or both, have been reported in glial and neuronal cells, in situ and in vitro . The nuclear structures appear spherical or rod-like and may have a positional relationship with nuclear pores [ 1 2 3 4 ] . Morphologically, these structures appear similar to the nuclear "speckles" that are thought to be storage sites for RNA splicing factors [ 5 6 7 ] . However, while intermediate filament (IF) phosphoproteins could be components of nuclear speckles, they are immunologically distinct.
Although these nuclear epitopes appear similar to nuclear speckles, the latter have not been reported as IF-associated structures, but rather storage sites of RNA processing proteins (see Sanford 2002, for a current, brief review [ 5 ] ). However, as it is know that lamins are involved in nucleo-skeletal organization [ 23 ] and organization of DNA replication sites [ 4 ] , it would not be unexpected to find lamins associated with nuclear speckles, perhaps as structural organizers.
The mutated proteins are located in cytoplasmic speckles similar to the N346 NLSmut1and N346 NLSmut3(Fig 7B).
These data link the bright, Rad26-GFP spots with the cell cycle arrest activities of the DNA damage checkpoint, and suggest that Rad26-GFP speckles play a role in recovery.
Results obtained with a Rad26.T12-GFP fusion protein suggest that the speckles are linked to repair activities, and the bright spots play a role in checkpoint-dependent cell cycle arrest.
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