Words similar to spatiotemporal
Example sentences for: spatiotemporal
How can you use “spatiotemporal” in a sentence? Here are some example sentences to help you improve your vocabulary:
Recent data suggest that in the developing nervous system, signaling by at least BMPs 2, 4 and 7 is determined by the spatiotemporal expression patterns of BMPs and their receptors, and by relative levels of the soluble BMP antagonists such as follistatin and noggin that directly bind BMPs in the extracellular compartment and prevent functional receptor/ligand interaction [ 1 24 25 26 27 28 ] . The extent to which these factors may regulate BMP-5 signaling is difficult to determine because of the paucity of data regarding either antagonism of BMP-5 signaling by follistatin and noggin or the interaction between known BMP receptors and BMP-5.
The handful of extremely valuable records that have allowed progress in understanding long-term patterns in disease dynamics pale in comparison to the spatiotemporal coverage available for climate studies and modeling.
To better understand the physiological role of the BMP family in ovarian function, the spatiotemporal expression patterns of a number of relevant BMP ligands, receptors, and a binding protein were determined by in situ hybridization in rat ovaries over the estrous cycle.
It is becoming increasingly evident that BMP signaling is regulated not only by the spatiotemporal expression of BMP ligands and receptors, but also by relative levels of soluble BMP antagonists, which directly bind BMPs and prevent functional receptor/ligand interaction [ 1 24 25 26 27 28 ] . The different BMP antagonists bind to BMPs and other TGF-β family members with varying degrees of specificity.
The delayed Gadolinium-Enhanced Magnetic Resonance Imaging of Cartilage (dGEMRIC) method overcomes these problems in that it is nondestructive and can be used to assess quantitatively the spatial distribution of cartilage [GAG] [ 12 13 ] . We and others previously reported on the use of dGEMRIC to monitor GAG regeneration in living cartilage tissue over time in trypsin-depleted bovine cartilage [ 14 ] and in cell-laden polymer matrices (tissue engineered cartilage) [ 15 ] . Those studies clearly demonstrated that dGEMRIC is feasible for long-term [GAG] monitoring, and that its sensitivity is sufficient to permit observation of the spatiotemporal evolution of [GAG].
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