Words similar to sodium-dependent

Example sentences for: sodium-dependent

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An alternative mechanism for the upregulation of IBAT in cystic fibrosis is that CFTR acts as a negative regulator of IBAT, as it does for the epithelial sodium channel [ 36 ] . As IBAT is a sodium-dependent apical membrane transporter, it might be regulated by CFTR, as is the epithelial sodium channel (ENaC) present in the apical membrane of the ileal enterocyte.
Bile acids are reclaimed from the lumen of the intestine and returned to the liver via portal blood for reuse [ 1 ] . The recovery of bile acids from the intestine is an efficient process that involves both passive transport along the entire axis of the intestine, and active transport in the terminal ileum [ 5 ] . The apical sodium/bile acid co-transporter (asbt) mediates the active uptake of conjugated bile acids in the ileum [ 5 6 ] . In hepatocytes, both sodium-dependent and sodium-independent transport systems on the sinusoidal membranes extract bile acids from portal blood.
The results indicate that bile acid malabsorption in CF is not caused by a defect in sodium-dependent bile acid transport at the brush border membrane suggesting another mechanism is operative.
The correlation between zygosity and level of IBAT protein expression suggests a close relationship between the function of the CFTR chloride channel and the sodium-dependent ileal bile acid transporter.