Words similar to snip
Example sentences for: snip
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The functional characterization of clone 19 (SNIP1) as a novel CBP/p300 interactor and repressor has been reported recently in the signaling pathways of TGF-β [ 25 ] . The functional characterization of clone 12 (SIP2) as a new member of the sorting nexin family member has also been reported [ 31 ] . Studies of the novel protein SIP3 will be reported separately (Paralkar et al, manuscript in preparation).
6E), we therefore tested Az interaction with SNIP1 in the presence of the co-expression of Smad1, Smad4 and ALK3Q233D.
The novel CBP/p300 repressor SNIP1 is recruited to Az upon the activation of BMP type I receptor
The inhibition of SNIP1 on CBP/p300 is considered to act through its interaction with the C/H1 domain of CBP/p300, thereby blocking the recruitment of CBP/p300 by other transcription factors including Smad4 [ 25 ] . Such an inhibition is counteracted by the ability of Smad4 to compete off SNIP1 from CBP/p300 [ 25 ] . So at early phase of Smad activation, although SNIP1 is still bound to Smad1 and Smad4, it is no longer directly bound to CBP/p300, which now can activate transcription.
This data further suggests that the inhibitory activity of SNIP1 is mediated by its interaction with CBP/p300, similar to what has been reported in the TGF-β pathways [ 25 ] . We next tested the inhibitory activity of SNIP1 on the transcriptional activity of Smad1, using the GAL4-Smad1 and GAL4-Luc reporter system, as described previously [ 42 43 ] . SNIP1 inhibited BMP-induced activation of GAL4-Luc in p19 cells transfected with GAL4-Smad1 (Fig.
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